Alkaline Diuresis as Treatment for 2, 4-D Dimethylamine Herbicide Intoxication: A Case Report
Nitesh Jindal, Tanu Raj Sirohi, Patamsetti Anil Kumar, Mohammad Shoeb, Gali Shabarish, Pediredla Sri Sowmya
International Journal of Medical and Pharmaceutical Case Reports · pp. 83–87 · Published 22 Nov 2022
10.9734/ijmpcr/2022/v15i4317Abstract
The use of 2, 4-D dimethylamine is expanding as a result of the rise in glyphosate and paraquat resistance in weeds [1]. Instances of 2,4D dimethylamine intoxication have been on the rise. This herbicide exhibits a range of dose-dependent harmful mechanisms, including cell membrane destruction, disruption of acetyl coenzyme A metabolism, and oxidative phosphorylation uncoupling [2]. The neurological system, heart, lungs, liver, muscles, and endocrine system may all be affected by toxic effects [3]. Results in male cases are fatal [2,4]. The usefulness of alkaline diuresis as a life-saving treatment for 2,4-D dimethylamine poisoning with severe symptoms is discussed in this paper. 2, 4-D dimethylamine intoxication can be fatal if not treated promptly. There is no particular antidote and alkaline diuresis shows good result in the patient who present with severe intoxication of 2, 4-D dimethylamine.
References (6)
- 1 Potential developmental neurotoxicity of pesticides used in Europe [DOI]
- 2 Mechanisms of Toxicity, Clinical Features, and Management of Acute Chlorophenoxy Herbicide Poisoning: A Review [DOI]
- 3 Poisoning Due to Chlorophenoxy Herbicides [DOI]
- 4 Intentional Self-Poisoning With the Chlorophenoxy Herbicide 4-Chloro-2-Methylphenoxyacetic Acid (MCPA) [DOI]
- 5 Treatment of severe 2,4‐D and mecoprop intoxication with alkaline diuresis. [DOI]
- 6 2, 4-D Dichlorophenoxyacetic Acid Poisoning; Case Report and Literature Review [DOI]
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