Analgesic, Anti-inflammatory and CNS Depressant Activities of the Methanolic Extract of Abelmoschus esculentus Linn. Seed in Mice
Mst. Luthfun Nesa, Md. Monirul Islam, Md. Badrul Alam, Mst. Shirajum Munira, Shabnam Mollika, Mst. Nazmun Naher, Md. Rafiqul Islam
Journal of Pharmaceutical Research International · pp. 849–860 · Published 13 Feb 2014
10.9734/BJPR/2014/7845Abstract
Aims: The study was carried out to assess the analgesic, anti-inflammatory and CNS depressant activity of the methanolic extract of Abelmoschus esculentus Linn. Seeds. Study Design: The Present study was designed to observe pharmacological activities of the crude extract of the plant Abelmoschus esculentus seeds. The study consisted of hot extraction of the seeds of the A. esculantus with methanol. Afterwards, Methanolic crude extract was filtered and the filtrate was evaporated. Finally, screening of analgesic, anti-inflammatory and CNS depressant activity of crude extracts of A. esculantus on Swiss Albino mice. Place and Duration of Study: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh. January, 2013- July 2013. Methodology: The animals are divided into Four groups and each group consists of five mice. Analgesic activity was performed by acetic acid-induced writhing model and formalin induced licking and biting in mice. Anti-inflammatory effects of Abelmoschus esculentus seed extract were done by carrageenan induced anti-inflammatory method at the dose of 100 and 200 mg/kg b.wt., (p.o). The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the hole cross and opens field tests at the dose of 100 and 200 mg/kg body weight. Results: In statistical analysis, the dose (200 mg/kg) was found to exhibit (significant p=0.05) better analgesic activity (65.16% and 54.38%) against both acetic acid and formalin induced pain in mice which is about similar to standard drug Indomethacin. The extract of A. esculentus (100 and 200mg/kg) also showed sustained inhibition (54.97% and 65.56%) of paw edema at the 4th hour compared to Indomethacin (74.17%). Besides this A. esculentus (significant p=0.05) seed extract (100 and 200mg/kg p.o.) also possesses depressant activity at 90min in both methods. Conclusion: this study recommends that the methanolic extract of the Abelmoschus esculentus seeds has significant CNS depressant, analgesic and anti-inflammatory properties.
References (24)
- 1 The formalin test: an evaluation of the method [DOI]
- 2 The formalin test in mice: dissociation between inflammatory and non-inflammatory pain [DOI]
- 3 Release of prostaglandins E and F in an algogenic reaction and its inhibition [DOI]
- 4 Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat [DOI]
- 5 Studies on the antinociceptive action of α‐agonist drugs and their interactions with opioid mechanisms [DOI]
- 6 Identification and quantification of polyphenolic compounds from okra seeds and skins [DOI]
- 7 STUDIES OF THE SPONTANEOUS MOVEMENT OF ANIMALS BY THE HOLE CROSS TEST; EFFECT OF 2-DIMETHYL-AMINOETHANOL AND ITS ACYL ESTERS ON THE CENTRAL NERVOUS SYSTEM [DOI]
- 8 Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States [DOI]
- 9 Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents.
- 10 l ‐NG‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse [DOI]
- 11 Methodological refinements to the mouse paw formalin test [DOI]
- 12 Chemical composition and the antioxidative properties of Nigerian Okra Seed (Abelmoschus esculentus Moench) Flour [DOI]
- 13 Influence of variety on protein, fat contents and some physical characteristics of okra seeds [DOI]
- 14 Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin‐induced orofacial nociception in rats [DOI]
- 15 Use of plant residues for improving soil fertility, pod nutrients, root growth and pod weight of okra (Abelmoschus esculentum L) [DOI]
- 16 Anti‐arthritic effect of scopoletin, a coumarin compound occurring in Erycibe obtusifolia Benth stems, is associated with decreased angiogenesis in synovium [DOI]
- 17 Oligo- and polysaccharides exhibit a structure-dependent bioactivity on human keratinocytes in vitro [DOI]
- 18 A PSYCHOPHARMACOLOGICAL ANALYSIS OF BEHAVIOR IN RAT
- 19 Influence of pre-treatment on yield chemical and antioxidant properties of a Nigerian okra seed (Abelmoschus esculentus moench) flour [DOI]
- 20 Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata
- 21 A new flavonol glycoside from the Abelmoschus esculentus Linn. [DOI]
- 22 The Analgesic and Anti-Inflammatory Activities of the Extracts of Phyllanthus reticulatus . in Mice Model [DOI]
- 23 Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals [DOI]
- 24 Locomotor Activity of Methanolic Extract of Saraca indica Bark
Cited by 21
Etlidawati, Bambang Purwanto, Soetrisno · Revista de Gestão Social e Ambiental · 2024
M. A. Akhtar · Frontiers in Pharmacology · 2022
S. Korani, Khodabakhsh Rashidi, Mona Hamelian · Bioinorganic Chemistry and Applications · 2021
Muhammad Luthfi, W. S. Juliastuti, Yuniar Aliyah Risky · Infectious Disease Reports · 2020
Muhammad Luthfi, W. S. Juliastuti, Yuniar Aliyah Risky · 2020
K. Mondal, S. Manandhar · 2019
Dharmesh K. Golwala, Santosh Kumar Vaidya, Timir B Patel · Current Issues in Pharmacy and Medical Sciences · 2020
Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo · Journal of Basic and Clinical Physiology and Pharmacology · 2017
Zhuocheng Li, Lei Zhang, Zhichao Zhao · Pain Research and Management · 2021
عبد المنعم صنع الله, فاطمة فوزي اميمة, حليمة محمد الرائس · مجلة البحوث الأكاديمية · 2017
Showing 11 of 21 known citations — external sources report more than can currently be individually listed.
Related research
- Evaluation of In-vitro Anti-Inflammatory, Anti-Fungal, Thrombolytic, Membrane Stabilizing and Cytotoxic Properties of (Camellia chrysantha Hu Tuyama) — shares topic coverage
- Therapeutic Potential of Ginger-supplemented Diet in Reversing Lead-induced Nephrotoxicity — shares topic coverage
- Synthesis, Characterization and Biological Evaluation of Thiazolidinedione Substituted Derivatives — shares topic coverage
- Anti-inflammatory and Anti-infective Properties of Ethanol Leaf and Root Extracts of Baphia nitida — shares topic coverage
- Ethnopharmacological Properties of Ceasalpinia benthamiana - A Mini Review — shares topic coverage
Article metrics
Real usage data collected on this platform.
24
Page views
0
PDF downloads
9
Outbound clicks
21
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.