Analysis of Motor Complications in Parkinson’s Disease Phenotypes

Abstract

Patients with PD were enrolled in the research study and underwent examination on movement disorder and drug-induced motor complication by UPDRS III and IV. Hoehn and Yahr scale was used to describe the intermediate course of disease. All antiparkinsonian drugs were calculated on theoretical equivalence to L-dopa. 208 patients were divided into three subgroups: tremor-dominant 50,4%, akinetic-rigid 41,9% and mix type 7,7%. All patients were treated with L-dopa, and about three quarters were in combination with a dopamine agonist.Regarding disease duration and developing of wearing off, there was significant difference according to clinical phenotype. AR and mix subtype of PD develop wearing off earlier within 3 years compare to TD. 72,4% TD type develop wearing off after 6 years and further while AR and Mix type develop earlier. It should be also noted that when gender was included in the analysis, we didn't found a positive association with wearing off as well as LID. Peak dose is the most found dyskinesia type in patients. The same no association with average LED with LID. Our findings support the hypothesis that tremor dominant type manifests with a bit benign clinic and complication.