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Research Article Open access CC BY 4.0

Anti-Inflammatory Activity of Ethanol Leaf Extract of Arthropteris Orientalis in Wistar Albino Rat

Akhigbe Faith Omoighele, Ckikere A. Anusiem, Samuel I. Ghasi, Ajirioghene E. Akpotu, Chidi E. Ezerioha, Funso-Babarimisa, Funso

Journal of Complementary and Alternative Medical Research · pp. 35–45 · Published 10 Nov 2023

10.9734/jocamr/2023/v24i3502

Abstract

The study investigated the anti-inflammatory activity of ethanol leaf extract of Arthropteris orientalis in wistar albino rat. The plant extract was obtained with the procedure as described by Khalifa et al. [1] and both acute and chronic anti-inflammatory properties was assessed. Five groups of five animals each were utilized for acute and chronic inflammation respectively. Anti-inflammatory effect of the extract was evaluated on egg albumin induced paw edema in albino rats and edema induced by formalin in the wistar albino rats’ paw for acute and chronic inflammation respectively. The extract had 26.665% tannin while flavonoid, saponin, phenol, and glycoside had 0.784%, 0.631%, 0.183% and 0.057% respectively. The result revealed that the extract at 500 mg/kg exhibited significant inhibition (p<0.05) of systemic acute paw edema at the 4th hour of the second phase of edema in comparison with the standard drug. The results reveal that intraperitoneal administration of ethanol leaf extract of Arthropteris orientalis on formalin-Induced paw edema in wistar albino rats at (100 and 500mg/kg) and (100mg/kg) exhibited significant inhibition (p<0.05) in mean paw volumes on day 1 and 2 respectively. The extract did not produce any significant hematological change. These results show that Arthropteris orientalis has potential anti-inflammatory properties.

Anti-inflammatory Arthropteris orientalis Formalin Hematology

References (15)

  1. 1 Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts [DOI]
  2. 2 Plant Secondary Metabolite Biosynthesis and Transcriptional Regulation in Response to Biotic and Abiotic Stress Conditions [DOI]
  3. 3 African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications [DOI]
  4. 4 Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials [DOI]
  5. 5 Quantitative phytochemical analysis of selected medicinal plant species by using various organic solvents
  6. 6 Handbook of biologically active phytochemicals and their activities
  7. 7 Anti-inflammatory activity of Theobroma cacao L. stem bark ethanol extract and its fractions in experimental models [DOI]
  8. 8 The aqueous extract ofOcimum gratissimumleaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats [DOI]
  9. 9 Evaluation of anti-inflammatory and wound healing potential of tannins isolated from leaf callus cultures of Achyranthes aspera and Ocimum basilicum.
  10. 10 Phytochemical Study and Biological Activity of Three Fern Species of the Asplenium Genus Growing in Bulgaria [DOI]
  11. 11 The Spirituality of Others and the WHO Discourse on Traditional Medicine [DOI]
  12. 12 Evaluation of Anti-inflammatory and Diuretic Effects of Ethanol Leaf Extract of Piper guineense on Wistar Albino Rats
  13. 13 Diversity and distribution of ferns on the campus of the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana [DOI]
  14. 14 Synthesis and reactions of some new (E)-2-сyano-N′-[1-(pyren-3-yl)ethylidene]acetohydrazide derivatives [DOI]
  15. 15 Journal of Diabetes and Endocrinology [DOI]

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