Anti-Inflammatory Activity of Ethanol Root Extract of Panicum maximum
John A. Udobang, Jude E. Okokon, Daniel N. Obot, Utibe A. Edem
Asian Journal of Biology · pp. 1–7 · Published 16 Sep 2020
10.9734/ajob/2020/v10i230101Abstract
Background: Panicum maximum root is used routinely to treat ailments such as malaria, fever, pains and inflammatory diseases by traditional medicine practitioners. Aim: The study evaluated the anti-inflammatory effect of P. maximum root so as to validate its uses by practitioners of traditional medicine. Methodology: The root of P. maximum (dried powdered material) was extracted in ethanol using cold maceration technique. The root crude extract (137 –547 mg/kg) of P. maximum was investigated for anti-inflammatory activity using various experimental models; carrageenan, egg albumin and xylene - induced edema models. Results: The root extract of P. maximum caused significant (p<0.05 – 0.001) reduction of inflammation induced by the phlogistic agents in a dose-dependent fashion. The recorded anti-inflammatory effects were comparable to those initiated by 100 mg/kg acetyl salicylic acid (ASA, standard drug) used in some of the models here. The anti-inflammatory effect of this plant may be attributed to the phytochemical constituents of the plant. Conclusion: The findings from this research confirm the ethnomedical use of Panicum maximum root in treating inflammatory conditions.
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