Antibacterial and Anticandidal Activities of New Flavonoids from Streptomyces sp. HK17; an Endophyte in Curcuma longa Linn
Thongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, Waya S. Phutdhawong
Journal of Pharmaceutical Research International · pp. 2357–2369 · Published 10 Oct 2014
10.9734/BJPR/2014/13326Abstract
Aims: The purpose of this study was to investigate the antibacterial and anticandidal activities of new flavonoids from Streptomyces sp. HK17 which was isolated from the root tissue of Curcuma longa Linn. Study Design: Experimental study. Place and Duration of Study: The study was carried out at the Department of Microbiology and Department of Chemistry, Faculty of Science, Silpakorn University, between February and May 2014. Methodology: The major active ingredients from the crude extract were purified by silica gel column chromatography, thin-layer chromatography. The diameters of the zones of inhibition and the Minimum Inhibitory Concentration (MIC) were determined using the paper disc diffusion and the microbroth dilution methods respectively. Results: The crude extract and purified compounds were tested for their antibacterial activity against Staphylococcus aureus ATCC25932, Bacillus cereus ATCC7064 and Bacillus subtilis ATCC6633, Escherichia coli ATCC10536 and Pseudomonas aeruginosa ATCC27853 and anticandidal activity against Candida albicans ATCC190088. The crude extract showed the highest activity against S. aureus and C. albicans, with MIC values of 32 µg/ml. The purified compounds 3 showed the lowest MIC (32 µg/ml) and Minimum Microbicidal Concentration (MMC) (128 µg/ml) against S. aureus and C. albicans with corresponding large diameter of the zone of inhibitions (25.5 and 25.2 mm respectively). Conclusion: This study has shown that the new flavonoids were first isolated and identified. These flavonoids produced by Streptomyces sp. HK17 have potential in antibacterial and anticandidal activities.
References (31)
- 1 Methods for characterization of Streptomyces species [DOI]
- 2 Antimicrobial activity of flavonoids [DOI]
- 3 Advances in flavonoid research since 1992 [DOI]
- 4 Medicinal plants and antimicrobial activity [DOI]
- 5 Flavonoids, a class of natural products of high pharmacological potency [DOI]
- 6 Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds [DOI]
- 7 Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology [DOI]
- 8 Composition and Antimicrobial Activity of the Essential Oils of Two Origanum Species [DOI]
- 9 Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus [DOI]
- 10 The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer [DOI]
- 11 Comparison of Antioxidant and Antimicrobial Activities of Tilia (Tilia Argentea Desf Ex DC), Sage (Salvia Triloba L.), and Black Tea (Camellia Sinensis) Extracts [DOI]
- 12 Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079. [DOI]
- 13 Extracts and molecules from medicinal plants against herpes simplex viruses [DOI]
- 14 Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphylococcus aureus [DOI]
- 15 Activity of plant flavonoids against antibiotic-resistant bacteria [DOI]
- 16 Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. [DOI]
- 17 Isolation of endophytic actinomycetes from selected plants and their antifungal activity [DOI]
- 18 DNA gyrase inhibitory and antibacterial activity of some flavones(1) [DOI]
- 19 Microbial and Enzymatic Transformations of Flavonoids [DOI]
- 20 Antiviral Activity of Compounds Isolated From Plants [DOI]
- 21 Isoflavanones from the Heartwood of Swartzia polyphylla and Their Antibacterial Activity against Cariogenic Bacteria. [DOI]
- 22 Screening of natural products for antimicrobial agents [DOI]
- 23 A Comparison of Active Site Binding of 4-Quinolones and Novel Flavone Gyrase Inhibitors to DNA Gyrase [DOI]
- 24 Hydroxylations and Methylations of Quercetin, Fisetin, and Catechin byStreptomycesgriseus [DOI]
- 25 Antibacterial activity of new flavonoids from Streptomyces sp. BT01; an endophyte in Boesenbergia rotunda (L.) Mansf. [DOI]
- 26 p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552) [DOI]
- 27 New Cyclopentenone Derivatives from an Endophytic Streptomyces sp. Isolated from the Mangrove Plant Aegiceras comiculatum [DOI]
- 28 4-Arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity
- 29 Biological Activity of Chemical Constituents Isolated from Streptomyces sp. Tc052, an Endophyte in Alpinia galanga [DOI]
- 30 A comprehensive view on 4-methyl-2-quinazolinamine, a new microbial alkaloid from Streptomyces of TCM plant origin [DOI]
- 31 Microbial transformations of non-steroid cyclic compounds
Cited by 8
Ayomide Emmanuel Fadiji, Olubukola Oluranti Babalola · Frontiers in Bioengineering and Biotechnology · 2020
Thongchai Taechowisa, Thanaporn Chuen-Im, Waya S. Phutdhawon · Pakistan Journal of Biological Sciences · 2024
Thongchai Taechowisan, Suchanya Chaisaeng, Waya S. Phutdhawong · Food and Agricultural Immunology · 2017
Diksha Sharma, Kamal Jeet, Sanjay Kumar · Research Journal of Pharmacognosy and Phytochemistry · 2024
Showing 4 of 8 known citations — external sources report more than can currently be individually listed.
Related research
- Characterization and Evaluation of the Antibacterial Activity of Silver Nanoparticles Synthesized by Green Method Using Phyllanthus emblica Leaf Extract — shares topic coverage
- Antibacterial and Phytochemical Activity of Gliricidia sepium against Poultry Pathogens — shares topic coverage
- Evaluation of Antibacterial Activity of Piper betel Leaves and Nigella sativa Seeds against Multidrug Resistant Food and Water Borne Pathogenic Bacteria: An in vitro Study Model — shares topic coverage
- Traditional and Molecular Identification of Bacterial Contamination from Honey (Processed and Unprocessed) and Their Control by Phytotherapy — shares topic coverage
- Antibacterial, Antioxidant Activity and Phytochemical Analysis of Euphorbia hirta Linn. — shares topic coverage
Article metrics
Real usage data collected on this platform.
25
Page views
0
PDF downloads
2
Outbound clicks
8
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.