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Research Article Open access CC BY 4.0

Anticonvulsant Activity of Some Medicinal Plants: A Review

Felix Keneolisa Asogwa, Ugwu Obiora Celestine, Ali Ibeabuchi Jude

International Neuropsychiatric Disease Journal · pp. 36–52 · Published 24 Dec 2022

10.9734/indj/2022/v18i3355

Abstract

Epilepsy is a central nervous system (neurological) disorder characterized by a bizarre feelings, sensations, and behaviors. Muscle spasms, convulsions, and loss of consciousness occasionally from epileptic seizures. Neuronal dependent on neurotransmitters in the central nervous system. In this review, we discussed epilepsy and its therapies, placing particular emphasis on some medicinal plants and their mechanism of action. The majority of herbal remedies that are both tested for anticonvulsant activity and utilized in ethno medicine to treat epilepsy were reported. The findings demonstrate that active components extracted from medicinal plants can prevent and treat neuronal disorder.

Transmitter excitotoxic neuronal plasticity seizure neurosyphilis

References (97)

  1. 1 Studies in Natural Products Chemistry [DOI]
  2. 2 Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial [DOI]
  3. 3 Adverse effects of antiepileptic drugs [DOI]
  4. 4 The consequences of refractory epilepsy and its treatment [DOI]
  5. 5 The pharmacological treatment of epilepsy in adults [DOI]
  6. 6 Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa [DOI]
  7. 7 Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities [DOI]
  8. 8 Imaging Spectrum of CNS Vasculitis [DOI]
  9. 9 Molecular mechanisms of antiseizure drug activity at GABAA receptors [DOI]
  10. 10 Review of Pharmacological Properties and Chemical Constituents of Pimpinella anisum [DOI]
  11. 11 Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia [DOI]
  12. 12 Molecular Genetics of Neuronal Migration Disorders [DOI]
  13. 13 High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic SeizuresIn Vitro [DOI]
  14. 14 Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents [DOI]
  15. 15 Research advances in basic mechanisms of seizures and antiepileptic drug action [DOI]
  16. 16 Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: Different performances regarding bioactivity and phenolic compounds [DOI]
  17. 17 Comparative efficacy of two interventions to discontinue long-term benzodiazepine use: cluster randomised controlled trial in primary care [DOI]
  18. 18 Neuronal migration disorders: Focus on the cytoskeleton and epilepsy [DOI]
  19. 19 Neurological findings in incontinentia pigmenti; a review [DOI]
  20. 20 Emergence of semiology in epileptic seizures [DOI]
  21. 21 Pathophysiology of epilepsy.
  22. 22 The Neuroprotective Effect of Curcumin and Nigella sativa Oil Against Oxidative Stress in the Pilocarpine Model of Epilepsy: A Comparison with Valproate [DOI]
  23. 23 Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models [DOI]
  24. 24 Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females [DOI]
  25. 25 Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain [DOI]
  26. 26 New trends in neuronal migration disorders [DOI]
  27. 27 Antiepileptic potential of flavonoids fraction from the leaves of Anisomeles malabarica [DOI]
  28. 28 Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission [DOI]
  29. 29 Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: Possible involvement of adenosine [DOI]
  30. 30 Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration [DOI]
  31. 31 Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice [DOI]
  32. 32 Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex [DOI]
  33. 33 Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch. [DOI]
  34. 34 A panoramic view on phytochemical, nutritional, ethanobotanical uses and pharmacological values of Trachyspermum ammi Linn. [DOI]
  35. 35 Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate [DOI]
  36. 36 Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy [DOI]
  37. 37 Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals [DOI]
  38. 38 The Dynamics of Neuronal Migration [DOI]
  39. 39 Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice [DOI]
  40. 40 Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts [DOI]
  41. 41 Epilepsy In Nigeria – A Review Of Etiology, Epidemiology And Management [DOI]
  42. 42 Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors [DOI]
  43. 43 Free radical scavenging and antiepileptic activity of Leucas lanata [DOI]
  44. 44 Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice [DOI]
  45. 45 Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain [DOI]
  46. 46 Cellular and Molecular Control of Neuronal Migration [DOI]
  47. 47 Malignant insulinoma misdiagnosed and treated as epilepsy [DOI]
  48. 48 Chemistry and Health Effects of Bioactive Compounds in Selected Culinary Aromatic Herbs [DOI]
  49. 49 Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet [DOI]
  50. 50 Chapter 12: What does the Anthropocene hold for citizenship? [DOI]
  51. 51 Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery [DOI]
  52. 52 Epilepsy in older people [DOI]
  53. 53 Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination [DOI]
  54. 54 Revisiting the role of neurotransmitters in epilepsy: An updated review [DOI]
  55. 55 Malformations of cortical development and epilepsy [DOI]
  56. 56 Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis [DOI]
  57. 57 An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy [DOI]
  58. 58 Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis [DOI]
  59. 59 The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review [DOI]
  60. 60 Mentha spicata L. essential oil, phytochemistry and its effectiveness in flatulence [DOI]
  61. 61 Therapeutic Effects of Curcumol in Several Diseases; An Overview [DOI]
  62. 62 Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy [DOI]
  63. 63 Artificial Intelligence and Computational Approaches for Epilepsy [DOI]
  64. 64 White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis [DOI]
  65. 65 Foodborne Pathogens [DOI]
  66. 66 Action of antiepileptic drugs on neurons [DOI]
  67. 67 A review on Cyperus rotundus A potential medicinal plant [DOI]
  68. 68 Antiepileptic drugs’ tolerability and safety – a systematic review and meta-analysis of adverse effects in dogs [DOI]
  69. 69 Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio) [DOI]
  70. 70 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish [DOI]
  71. 71 Transient Morphological Alterations in the Hippocampus After Pentylenetetrazole-Induced Seizures in Rats [DOI]
  72. 72 Sweet flag (Acorus calamus Linn.): An incredible medicinal herb [DOI]
  73. 73 Excitatory/Inhibitory Synaptic Ratios in Polymicrogyria and Down Syndrome Help Explain Epileptogenesis in Malformations [DOI]
  74. 74 Prevalence and burden of epilepsy in Nigeria: A systematic review and meta-analysis of community-based door-to-door surveys [DOI]
  75. 75 A Comprehensive Review of Bunium persicum: A Valuable Medicinal Spice [DOI]
  76. 76 Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control [DOI]
  77. 77 Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy [DOI]
  78. 78 Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model [DOI]
  79. 79 Pharmacoinformatics based screening discovers swertianolin from Lavandula angustifolia as a novel neuromodulator targeting epilepsy, depression, and anxiety [DOI]
  80. 80 Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release [DOI]
  81. 81 Reducing Glutamate Uptake in Rat Hippocampal Slices Enhances Astrocytic Membrane Depolarization While Down-Regulating CA3–CA1 Synaptic Response [DOI]
  82. 82 EEG-based classification of normal and seizure types using relaxed local neighbour difference pattern and artificial neural network [DOI]
  83. 83 GABA Receptors Can Depolarize the Neuronal Membrane Potential via Quantum Tunneling of Chloride Ions: A Quantum Mathematical Study [DOI]
  84. 84 Anticonvulsant effects of medicinal plants with emphasis on mechanisms of action [DOI]
  85. 85 Awareness and current knowledge of epilepsy [DOI]
  86. 86 Anticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice [DOI]
  87. 87 Anticonvulsant activity of methanolic extract of Withania cogulans in mice [DOI]
  88. 88 Epidemiology of brain tumors among adolescents and young adults in Nigeria [DOI]
  89. 89 Novel effect of Arthrocen (avocado/soy unsaponifiables) on pentylenetetrazole-induced seizure threshold in mice: Role of GABAergic pathway [DOI]
  90. 90 Seizures and Epilepsy: An Overview [DOI]
  91. 91 Essential Oil Constituents and Pharmacognostic Evaluation of Java Citronella (Cymbopogon winterianus) stem from Bandung, West Java, Indonesia [DOI]
  92. 92 Effects of onopordia, a novel isolated compound from Onopordon acanthium, on pentylenetetrazole-induced seizures in mice: Possible involvement of nitric oxide pathway [DOI]
  93. 93 Medicinal properties of Garlic: a review [DOI]
  94. 94 Anticonvulsant Activity of Methanol Extract of Harungana madagascariensis Leaf on Mice Model of Isoniazid-induced Siezure [DOI]
  95. 95 Nature's Medicines to Treat Epileptic Seizures [DOI]
  96. 96 ANTIMICROBIAL ACTIVITY OF PSIDIUM GUAJAVA LEAVES EXTRACT AGAINST STAPHYLOCOCCUS AUREUS USING PURE EXTRACTS [DOI]
  97. 97 Fluids and Electrolytes [DOI]

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