Skip to content
Research Article Open access CC BY 4.0

Antidiabetic Activity of Apigenin (4, 5, 7 – Trihydroxy Flavone) from Leaves of Stachytarpheta jamaicensis (L) Vahl (Verbennaceae)

Uchenna Estella Odoh, Payare Lal Sangwan, Ikenna Stanley Odoh

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 50–60 · Published 26 Sep 2023

10.9734/jamps/2023/v25i8636

Abstract

Background: Apigenin is a polyphenolic compound that belongs to the class of flavonoids and is considered highly therapeutic. Aim: To evaluate the antidiabetic activity of apigenin isolated from dichloromethane: methanol extract of leaves of Stachytarpheta jamiacensis (L) Vahl (Verbennaceae) in alloxan-induced diabetic rats. Methods: Cold maceration was used to extract the S. jamiacensis powdered leaves with dichloromethane: methanol (1:1). Hexane, dichloromethane, and aqueous methanol fractions of the extract were obtained through fractionation. To isolate the bioactive molecule, the dichloromethane fraction (DCMF) was then subjected to column chromatography and eluted with several solvent mixtures in ascending polarity order. With the aid of data from FTIR, UV, GC-MS, 1HNMR (400MHz), and 13CNMR (101MHz), the structure of the isolated compound was identified. The Phytochemical analysis of the isolate and acute toxicity study was done following standard procedures. The anti-diabetic potential of the isolate was assessed by determining fasting blood glucose levels on alloxan-induced rats at the dose of 25 and 50 mg/kg body weight. Results: The compound was identified as apigenin  (4, 5, 7 – trihydroxy flavones) and showed significant (p<0.05) reduction of 79.56 and 81.74 % in fasting blood glucose levels at the dose of 25 and 50 mg/kg respectively when compared with the standard drug (glibenclamide 83.40 %). The isolate's phytochemical analysis revealed flavonoids and the LD50 test demonstrates that apigenin was not harmful. Conclusion: The findings show that the apigenin from Stachytarpheta jamaicensis (L) Vahl has potent anti-diabetic properties.

Stachytarpheta jamaicensis apigenin antidiabetic phytochemical analysis

References (29)

  1. 1 A new approach to practical acute toxicity testing [DOI]
  2. 2 Flavonoids, a class of natural products of high pharmacological potency [DOI]
  3. 3 Techniques of flavonoid identification: [DOI]
  4. 4 Effects of flavonoids on immune and inflammatory cell functions [DOI]
  5. 5 On the mechanism of antithrombotic action of flavonoids [DOI]
  6. 6 Diabetes in Africa: epidemiology, management and healthcare challenges [DOI]
  7. 7 Cell-Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines [DOI]
  8. 8 Herbal medicines for diabetes mellitus: a review.
  9. 9 Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications [DOI]
  10. 10 Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus [DOI]
  11. 11 Bioactive compounds and health benefits of edible Rumex species-A review [DOI]
  12. 12 Therapeutic and pharmacological potential of Foeniculum vulgare Mill: a review
  13. 13 Late Stage Complications of Diabetes and Insulin Resistance [DOI]
  14. 14 Ethnobotany of the genus Taraxacum —Phytochemicals and antimicrobial activity [DOI]
  15. 15 A Review of Types 1 and 2 Diabetes Mellitus and Their Treatment with Insulin [DOI]
  16. 16 In vitro antimalarial activity and cytotoxicity of some selected cuban medicinal plants [DOI]
  17. 17 A Review on Fruits Having Anti-Diabetic Potential
  18. 18 Antibacterial activity of some Lamiaceae species against Staphylococcus aureus in yoghurt-based drink (Doogh) [DOI]
  19. 19 Veronica persica Poir. extract – antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase [DOI]
  20. 20 Mortality patterns among type 2 diabetes mellitus patients in Ilorin, Nigeria [DOI]
  21. 21 Preliminary Phytochemistry, Antimicrobial Properties and Acute Toxicity of Stachytarpheta jamaicensis (L.) Vahl.Leaves [DOI]
  22. 22 Pulicaria vulgaris Gaertn. essential oil: an alternative or complementary treatment for Leishmaniasis [DOI]
  23. 23 Prevalence of adult diabetes in Ibadan, Nigeria.
  24. 24 Antibacterial potential of Saussurea obvallata petroleum ether extract: A spiritually revered medicinal plant [DOI]
  25. 25 Antinociceptive and Anti-Inflammatory Effects of Stachytarpheta jamaicensis (L.) Vahl (Verbenaceae)in Experimental Animal Models [DOI]
  26. 26 Cell‐Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines [DOI]
  27. 27 SCREENING OF ETHANOLIC EXTRACT OF STACHYTARPHETA INDICA L. (VAHL) LEAVES FOR HEPATOPROTECTIVE ACTIVITY
  28. 28 Wound healing potential of the crude leaf extract of Stachytarpheta Jamaicensis Linn. Vahl (Kandikandilaan) on inducedwounds in rats
  29. 29 Antimicrobial activity and cytotoxic effects of stachytarpheta jamaicensis (L.) vahl crude plant extracts

Cited by 1

Aktivitas Hepatoprotektor Ekstrak Akar Pecut Kuda (Stachytarpheta jamaicensis) Terhadap Mencit Terinduksi Paracetamol

Rr. Erni Kusuma Putri, M. Yuswar, Ari Widiyantoro · Jurnal Laboratorium Khatulistiwa · 2025

Related research

Article metrics

Real usage data collected on this platform.

28

Page views

0

PDF downloads

3

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.