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Antifungal Effect of Flavonoid 5, 7, 4’-Trimethoxyflavone against Candida krusei Strains

Abrahão Alves de Oliveira Filho, Heloísa Mara Batista Fernandes, Janiere Pereira de Sousa, Gabriela Lemos de Azevedo Maia, José Maria Barbosa Filho, Thais Josy Castro Freire de Assis, Hilzeth Luna Freire Pêssoa, Edeltrudes Oliveira Lima

International Journal of TROPICAL DISEASE & Health · pp. 36–140 · Published 15 Nov 2014

10.9734/IJTDH/2015/14060

Abstract

Most of the flavonoids are considered as constitutive antimicrobial ingredients, especially those belonging to prenylated flavonoids, flavones and isoflavones. In the study, the flavonoid 5,7,4’-trimethoxyflavone was evaluated for its antifungal effects. Four fungal strains were used in the study for activities, Candida krusei – LM 9700, Candida krusei – LM 656, Candida krusei– LM 13 and Candida krusei – LM08. All the microorganism strains were obtained from the Laboratory of Mycology collection. Microdilution method was used for antifungal assay of the flavonoid. The results were also compared with the standard drug, Nistatin (100 UI/mL). The obtained results showed activity fungistatic against Candida krusei strains.

Flavonoid nistatin antifungal Candida krusei.

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