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Research Article Open access CC BY 4.0

Antihyperlipidemic Studies of Methanolic Extract of Gossypium herbaceum: An In silico and In vivo Approach

N. V. L. Suvarchala Reddy V, M. Ganga Raju, M. Mamatha, Shabnam Kumari Thakur

Asian Journal of Research in Medical and Pharmaceutical Sciences · pp. 32–42 · Published 13 Aug 2022

10.9734/ajrimps/2022/v11i330193

Abstract

Aim: To evaluate anti-hyperlipidemic activity of the whole plant of Gossypium herbaceum extract in Wistar Albino Rats. Methods: The whole plant of Gossypium herbaceum were collected and extracted with methanol by soxhlation. It was tested in Triton and Propylthiouracil (PTU) induced hyperlipidemic rat models and antioxidant hydrogen peroxide radical scavenging assay. Results: Basic phytochemical tests resulted in the presence of flavonoids, terpenoids, steroids, phytosterols, carbohydrates, alkaloids, tannins and phenolic compounds. In rat models of hyperlipidemia induced by Triton and Propylthiouracil (PTU), the anti-hyperlipidemic effect of a methanolic extract of the whole plant of Gossypium herbaceum was studied. MEGH (200 and 400 mg/kg, p.o.) treatment greatly decreased the enhanced serum lipids, restored the decreased HDL compared to disease group. Histopathological examinations showed recovery of the damaged liver cells in Propylthiouracil treated group. The extract's capacity to scavenge free radicals caused by hydrogen peroxide was also measured. Ascorbic acid served as the reference. The result demonstrates that the Gossypium herbaceum whole plant's methanolic extract has substantial antioxidant and antihyperlipidemic properties. Docking simulation was done to PDB protein of Lecithin cholesterol acyltransferase, HMG-CoA reductase inhibitor and Antoxidant and viewed in discover studio followed by Ramachandran plot. Conclusion: Methanolic extract of Gossypium herbaceum can be used for management of hyperlipidemia and possess antioxidant activities.

Triton-X-100 propylthiouracil hyperlipidemia antioxidant Gossypium herbaceum whole plant rats atrovastatin

References (8)

  1. 1 Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats [DOI]
  2. 2 In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn [DOI]
  3. 3 Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats [DOI]
  4. 4 Antioxidant and anti-hyperlipidemic activity of hydroethanolic seed extract of Aframomum melegueta K. Schum in Triton X-100 induced hyperlipidemic rats [DOI]
  5. 5 Hypolipidemic effect and activation of Lecithin Cholesterol Acyl Transferase (LCAT) by aqueous extract of Spirulina platensis during toxicological investigation [DOI]
  6. 6 In silico designing and molecular docking of a potent analog against Staphylococcus aureus porphobilinogen synthase [DOI]
  7. 7 Effects of Honey on Postprandial Hyperlipidemia and Oxidative Stress in Wistar Rats: Role of HMG-CoA Reductase Inhibition and Antioxidant Effect.
  8. 8 Management of Primary Mixed Hyperlipidemia With Lovastatin [DOI]

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