Skip to content
Research Article Open access CC BY 3.0

Application of Biotechnologycal Methods for Removal of Phenylalanıne from Different Protein Sources

Sema Kalkan Uçar, Mahmut Çoker, Hatice Kalkan Yildirim

Annual Research & Review in Biology · pp. 4529–4534 · Published 22 Aug 2014

10.9734/ARRB/2014/8880

Abstract

Inborn errors of amino acid metabolism include inherited biochemical disorders in which a specific enzyme defect interferes with the normal metabolism of protein. In these disorders as a result of diminished or absent enzyme activity, certain compounds accumulate in the body to toxic levels. Metabolic disturbances can lead to severe cognitive impairment and even death. Phenylketonuria, is the most common amino acid disorder. Dietary restriction prevent the accumulation of a substrate to toxic levels to a certain extend but application of biotechnological methods could provided more promising tools. The main topics discussed are: removal of phenylalanine by activated carbon, by tailored enzymatic hydrolyses of cheese whey, by modified corn cobs as adsorbents and by using enzymatic membrane reactor.

Phenylketonuria biotechnological methods

References (22)

  1. 1 Protein hydrolysis using proteases: An important tool for food biotechnology [DOI]
  2. 2 Neonatal screening in Europe; the situation in 2004 [DOI]
  3. 3 Newborn screening in Latin America at the beginning of the 21st century [DOI]
  4. 4 Nutritional Management of Phenylketonuria [DOI]
  5. 5 Intercurrent illness in inborn errors of intermediary metabolism. [DOI]
  6. 6 Nutritional treatment for inborn errors of metabolism: Indications, regulations, and availability of medical foods and dietary supplements using phenylketonuria as an example [DOI]
  7. 7 Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents [DOI]
  8. 8 Inborn errors of metabolism: Psychosocial challenges and proposed family systems model of intervention [DOI]
  9. 9 Executive functioning in children and adolescents with phenylketonuria [DOI]
  10. 10 Removal of phenylalanine from aqueous solutions with thermo-chemically modified corn cobs as adsorbents [DOI]
  11. 11 Use of activated carbon for removing phenylalanine from reconstituted skim milk powder hydrolysates [DOI]
  12. 12 Producing a phenylalanine-free pool of peptides after tailored enzymatic hydrolyses of cheese whey [DOI]
  13. 13 Dietary management of inborn errors of metabolism [DOI]
  14. 14 Technological challenges and strategies for developing low-protein/protein-free cereal foods for specific dietary management [DOI]
  15. 15 A new conception of enzymatic membrane reactor for the production of whey hydrolysates with low contents of phenylalanine [DOI]
  16. 16 Enzymatic Production of a Low‐Phenylalanine Product from Skim Milk Powder and Casemate [DOI]
  17. 17 The adolescent with an inborn error of metabolism: medical issues and transition to adulthood.
  18. 18 Evaluation of the performance of an agricultural residue-based activated carbon aiming at removal of phenylalanine from aqueous solutions [DOI]
  19. 19 Hydrolysis degree, peptide profile and phenylalanine removal from whey protein concentrate hydrolysates obtained by various proteases [DOI]
  20. 20 Phenylketonuria: practical dietary management.
  21. 21 Nutrition in metabolic disease [DOI]
  22. 22 Practical dietary management

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

36

Page views

0

PDF downloads

4

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.