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Research Article Open access CC BY 4.0

Approach to Anaemia Diagnosis in Developing Countries: Focus on Aetiology and Laboratory Work-Up

S. Adewoyin Ademola

International Blood Research & Reviews · pp. 1–13 · Published 4 Aug 2015

10.9734/IBRR/2015/19078

Abstract

Introduction: Anaemia is a significant public health problem in developing countries. Anaemia is never normal. The etiology of the anaemia should always be sought. Diagnosis of its cause and early treatment is crucial to improving the quality of life among affected persons. There is a need to provide practicing physicians with a good theoretical framework and a practical algorithm for arriving accurately at anaemia diagnosis. Objective: This article seeks to collect, collate and concisely review anaemias with emphasis on the prevalent aetiologies and laboratory diagnosis in developing countries Results: The etiology of anaemia in developing countries is myriad and requires accurate diagnosis. Nutritional (substrate) deficiencies and chronic diseases account for a significant proportion of acquired anaemias. The predominating inherited causes include haemoglobinopathies, red cell enzymopathies and membranopathies. A systematic approach will help the physician paddle through the large list of differentials, to cone down on precise diagnosis. Relevant clinical history, physical examination and baseline investigations are imperative. Further evaluations should be conducted in unresolved cases using suggested practical algorithms such as the morphologic and/or kinetic approach. Conclusion: Baseline investigations including full blood count, reticulocyte count and peripheral blood film should be requested on patients presenting with anaemia. Relevant authorities should ensure availability of these basic tests in all health facilities. Consultations with hematology unit should be engaged when necessary.  

Anaemia diagnosis laboratory work-up anaemia work-up developing countries

References (42)

  1. 1 Anemia of Chronic Disease [DOI]
  2. 2 Wintrobe's Clinical Hematology [DOI]
  3. 3 Dacie and Lewis Practical Haematology [DOI]
  4. 4 TROPICAL MEDICINE AND INTERNATIONAL HEALTH [DOI]
  5. 5 Guidelines for the diagnosis and management of aplastic anaemia [DOI]
  6. 6 Pathophysiology of anaemia: focus on the heart and blood vessels [DOI]
  7. 7 The prevalence of anaemia in women : a tabulation of available information
  8. 8 Report of a WHO Scientific Group [DOI]
  9. 9 The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa [DOI]
  10. 10 Haemoglobin adjustments to define anaemia [DOI]
  11. 11 Evaluation of macrocytosis.
  12. 12 Peripheral blood film - a review.
  13. 13 Anemia in chronic kidney disease: causes, diagnosis, treatment. [DOI]
  14. 14 Megaloblastic Anæmias [DOI]
  15. 15 Recombinant erythropoietin in clinical practice [DOI]
  16. 16 The Relation of Conjunctival Pallor to the Presence of Anemia [DOI]
  17. 17 Influence of clinical factors on the haemolysis marker haptoglobin [DOI]
  18. 18 Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials [DOI]
  19. 19 Usefulness of Physical Examination in Detecting the Presence or Absence of Anemia [DOI]
  20. 20 Diagnosis and treatment of unexplained anemia with iron deficiency without overt bleeding.
  21. 21 Clinical spectrum of myelophthisis in cancer patients [DOI]
  22. 22 Anemia among children aged 2–5 years in the Gaza Strip- Palestinian: a cross sectional study [DOI]
  23. 23 Autoimmune haemolytic anaemia - a practical guide to cope with a diagnostic and therapeutic challenge.
  24. 24 Pathogenesis, diagnosis, and management of disseminated intravascular coagulation: a literature review.
  25. 25 Molecular epidemiology and activity of erythrocyte G6PD variants in a homogenous Nigerian population [DOI]
  26. 26 Paroxysmal Nocturnal Haemoglobinuria [DOI]
  27. 27 Malaria in pregnancy and its consequences for the infant in rural Malawi [DOI]
  28. 28 Bone Marrow Aspiration [DOI]
  29. 29 Malaria and its burden among pregnant women in parts of the Niger Delta area of Nigeria [DOI]
  30. 30 Prevalence and Risk Factors of Anaemia in Older Hospitalised Patients [DOI]
  31. 31 Investigation of anaemia [DOI]
  32. 32 Malaria in pregnancy and its consequences for the infant in rural Malawi [DOI]
  33. 33 Epidemiological Study of Glucose-6-phosphate Dehydrogenase Deficiency in Scheduled Caste Population of India [DOI]
  34. 34 Usefulness of physical examination in detecting the presence or absence of anemia [DOI]
  35. 35 Anaemia in Critically Ill Children- A Case Study from Nigeria [DOI]
  36. 36 Paroxysmal nocturnal haemoglobinuria [DOI]
  37. 37 Differential diagnosis of anemia [DOI]
  38. 38 Acquired haemolytic anaemias [DOI]
  39. 39 Diagnostic Evaluation of Anaemia [DOI]
  40. 40 Recommendations to Prevent and Control Iron Deficiency in the United States [DOI]
  41. 41 Laboratory Techniques for the Identification of Abnormalities of Globin Chain Synthesis [DOI]
  42. 42 Acquired Coagulation Disorders [DOI]

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