Skip to content
Research Article Open access CC BY 4.0

AQP2 Genes and Nephrogenic Diabetes Insipidus: A Review

Monica Soni, Arvind Pareek

Annual Research & Review in Biology · pp. 1–8 · Published 9 Nov 2015

10.9734/ARRB/2015/22224

Abstract

Nephrogenic Diabetes insipidus (NDI) is an issue coming about because of lacking against diuretic hormone (ADH) activity and is described by the entry of extensive measures of exceptionally dilute urine. This problem must be separated from other polyuric states, for example, essential polydipsia, osmotic diuresis and diabetes mellitus.  Diabetes insipidus is a condition when a person is passing urine with excess of water, this condition arise due to improper re-absorption of water during urine formation. Aquaporins (AQPs) play a important role in absorption of water. AQP2 is quite dominant than other isoforms. This article provides nutshell information about Diabetes Insipidus and role of Aquaporin-2 gene in its physiology.

AQP2 Nephrogenic diabetes insipidus Vesopressin

References (29)

  1. 1 A Statistical Method for Evaluating Systematic Relationships [DOI]
  2. 2 The Proteomics Protocols Handbook [DOI]
  3. 3 Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. [DOI]
  4. 4 Cloning and expression of apical membrane water channel of rat kidney collecting tubule [DOI]
  5. 5 Journal of the American Society of Nephrology [DOI]
  6. 6 Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine [DOI]
  7. 7 Structure and function of aquaporin water channels [DOI]
  8. 8 Aquaporin CHIP: the archetypal molecular water channel [DOI]
  9. 9 Molecular Biology of Hereditary Diabetes Insipidus [DOI]
  10. 10 Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus [DOI]
  11. 11 Regulation of Aquaporin-2 Trafficking [DOI]
  12. 12 Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment [DOI]
  13. 13 The AQP2 water channel: Effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats [DOI]
  14. 14 Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct. [DOI]
  15. 15 Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.
  16. 16 Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats [DOI]
  17. 17 Nephrogenic Diabetes Insipidus [DOI]
  18. 18 Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus.
  19. 19 Molecular and cellular defects in nephrogenic diabetes insipidus [DOI]
  20. 20 Localization and trafficking of aquaporin 2 in the kidney [DOI]
  21. 21 Trafficking mechanism of water channel aquaporin‐2 [DOI]
  22. 22 Oxytocin and Vasopressin: Genetics and Behavioral Implications [DOI]
  23. 23 Aquaporins: The renal water channels [DOI]
  24. 24 Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V) [DOI]
  25. 25 DNA structure, mutations, and human genetic disease [DOI]
  26. 26 Effect of the cGMP pathway on AQP2 expression and translocation: potential implications for nephrogenic diabetes insipidus [DOI]
  27. 27 Vasopressin receptors in health and disease [DOI]
  28. 28 A novel pattern recognition algorithm to classify membrane protein unfolding pathways with high-throughput single-molecule force spectroscopy [DOI]
  29. 29 Structure and function of AQP2 [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

18

Page views

0

PDF downloads

3

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.