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Research Article Open access CC BY 4.0

Association between Age Gain, Parkinsonism and Pesticides: A Public Health Problem?

Renata Cristina-Pereira, Kaynara Trevisan, Ediana Vasconcelos-da-Silva, Sylla Figueredo-da-Silva, Micheli Patricia de F. Magri, Lisandre F. Brunelli, Tales Alexandre Aversi-Ferreira

International Neuropsychiatric Disease Journal · pp. 44–73 · Published 6 May 2023

10.9734/indj/2023/v19i3376

Abstract

As life expectancy increases worldwide, so does the time available for prolonged exposure to toxic materials in the environment that have the potential to exert gradual pressure, facilitating the onset of aging in the body. Neural/behavioral alterations are linked to age gain, making the understanding of the aging process more complex considering the high complexity of the neural system and, although neuropsychological, pathological and neuroimaging criteria have been established to differentiate between normal and pathological aging, diagnosing the mild cognitive problems of each elderly individual remains a challenge. Parkinson's disease is recognized as one of the most common neurological disorders in the elderly, whose intrinsic cause is still unknown, but its main molecular basis is the decrease in dopamine produced in the substantia nigra. Studies have suggested that exposure to organophosphate, the glyphosate class, in different organisms, are capable of promoting bodily malformations, neurotoxicity, hepatotoxicity, genotoxicity, metabolic disorders, among others. The effects of pesticides on the environment, associated with their exacerbated permanence in the environment, indicate that more and more people may suffer their deleterious action, which may be the cause of some neurodegenerative disorders. The main objective of this study was to use specific data from the literature on Parkinsonism, correlating it with aging and contamination by pesticides. In fact, the health risks inherent in the use of pesticides are greater the greater the intensity of exposure to them and, considering the widespread use of pesticides today, the number of poisoning of the human population and animals will increase. Therefore, in terms of literary data, contamination with pesticides may be associated with a public health problem and, therefore, a possible increase in dementia processes, thus Parkinsonism.

Aging parkinsonism pesticide toxicity glyphosate

References (125)

  1. 1 The Hallmarks of Aging [DOI]
  2. 2 Geroscience: Linking Aging to Chronic Disease [DOI]
  3. 3 Subjective wellbeing, health, and ageing [DOI]
  4. 4 The burden of disease in older people and implications for health policy and practice [DOI]
  5. 5 Normal Cognitive Aging [DOI]
  6. 6 The clinical symptoms of Parkinson's disease [DOI]
  7. 7 Ageing and Parkinson's disease: Why is advancing age the biggest risk factor? [DOI]
  8. 8 Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats [DOI]
  9. 9 What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus [DOI]
  10. 10 Physiological responses of the European cockle Cerastoderma edule (Bivalvia: Cardidae) as indicators of coastal lagoon pollution [DOI]
  11. 11 Resting-state functional connectivity in normal brain aging [DOI]
  12. 12 Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis.
  13. 13 Epidemiology of Parkinson's disease [DOI]
  14. 14 A synopsis on aging—Theories, mechanisms and future prospects [DOI]
  15. 15 Generating Neuronal Diversity in the Mammalian Cerebral Cortex [DOI]
  16. 16 Literature review: Impact of climate change on pesticide use [DOI]
  17. 17 A review of physical and cognitive interventions in aging [DOI]
  18. 18 Changes during aging and their association with malnutrition [DOI]
  19. 19 Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles [DOI]
  20. 20 Impact of Fertilizers and Pesticides on Soil Microflora in Agriculture [DOI]
  21. 21 Anodal Transcranial Direct Current Stimulation Temporarily Reverses Age-Associated Cognitive Decline and Functional Brain Activity Changes [DOI]
  22. 22 Aging, the Central Nervous System, and Mobility [DOI]
  23. 23 Anatomy of the vestibular system: A review [DOI]
  24. 24 Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: A systematic review [DOI]
  25. 25 Progress in gene therapy for neurological disorders [DOI]
  26. 26 Brain Changes in Older Adults at Very Low Risk for Alzheimer's Disease [DOI]
  27. 27 The Differential Diagnosis and Treatment of Atypical Parkinsonism [DOI]
  28. 28 Acute organophosphorus poisoning [DOI]
  29. 29 Cerebral Cortex: Architecture, Connections, and the Dual Origin Concept
  30. 30 The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan [DOI]
  31. 31 Household organophosphorus pesticide use and Parkinson’s disease [DOI]
  32. 32 Brain cortical thickness in the general elderly population: The Rotterdam Scan Study [DOI]
  33. 33 Perspectives on Aging Vestibular Function [DOI]
  34. 34 Biological theories of aging [DOI]
  35. 35 Atypical parkinsonism [DOI]
  36. 36 Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice [DOI]
  37. 37 Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer [DOI]
  38. 38 Age and Parkinson's disease related kinematic alterations during multi-directional gait initiation [DOI]
  39. 39 Determinants of healthy lifestyle and its related factors among elderly people [DOI]
  40. 40 Atypical Parkinsonism [DOI]
  41. 41 Neurodevelopmental consequences of gestational and lactational exposure to pyrethroids in rats [DOI]
  42. 42 Parkinson’s disease, parkinsonism, and traumatic brain injury [DOI]
  43. 43 Drug-induced Parkinson's disease. A clinical review [DOI]
  44. 44 Drugs of abuse and Parkinson's disease [DOI]
  45. 45 Building an RNA Sequencing Transcriptome of the Central Nervous System [DOI]
  46. 46 The role of the nervous system in aging and longevity [DOI]
  47. 47 Organophosphate Toxicity [DOI]
  48. 48 Parkinsonism-Plus Syndromes [DOI]
  49. 49 Cochrane Database of Systematic Reviews [DOI]
  50. 50 The Ageing Body – Body Functions and Structures: Part 1 [DOI]
  51. 51 Ageing as a risk factor for neurodegenerative disease [DOI]
  52. 52 Worldwide pesticide usage and its impacts on ecosystem [DOI]
  53. 53 Pesticides, environment, and food safety [DOI]
  54. 54 Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies [DOI]
  55. 55 Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing [DOI]
  56. 56 Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology [DOI]
  57. 57 Prevalence of Parkinson’s disease across North America [DOI]
  58. 58 The genetic architecture of the human cerebral cortex [DOI]
  59. 59 Parkinson's Disease and Parkinsonism [DOI]
  60. 60 Population aging in Brazil: current and future social challenges and consequences [DOI]
  61. 61 Calorie restriction in humans: An update [DOI]
  62. 62 Molecular and physiological manifestations and measurement of aging in humans [DOI]
  63. 63 The history and current status of glyphosate [DOI]
  64. 64 Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis [DOI]
  65. 65 New insights into the development of the human cerebral cortex [DOI]
  66. 66 Effects of Chemical Fertilizers and Pesticides on Human Health and Environment: A Review [DOI]
  67. 67 Vascular, glial, and lymphatic immune gateways of the central nervous system [DOI]
  68. 68 Parkinson's disease: A review [DOI]
  69. 69 Ageing Process and Physiological Changes [DOI]
  70. 70 The Threshold Theory for Parkinson's Disease [DOI]
  71. 71 Diagnostic Approach to Atypical Parkinsonian Syndromes [DOI]
  72. 72 Climate change exacerbates pest damage through reduced pesticide efficacy [DOI]
  73. 73 Theories of Aging and the Prevalence of Alzheimer’s Disease [DOI]
  74. 74 Balance Control Mediated by Vestibular Circuits Directing Limb Extension or Antagonist Muscle Co-activation [DOI]
  75. 75 Healthy aging from the perspective of the elderly: an integrative review [DOI]
  76. 76 Depopulation and the Aging Population: The Relationship in Italian Municipalities [DOI]
  77. 77 The Aging Vestibular System: Dizziness and Imbalance in the Elderly [DOI]
  78. 78 Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy [DOI]
  79. 79 The effect of small vessel disease on motor and cognitive function in Parkinson’s disease [DOI]
  80. 80 Rest tremor revisited: Parkinson’s disease and other disorders [DOI]
  81. 81 Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease [DOI]
  82. 82 Pesticides and Related Toxicants in the Atmosphere [DOI]
  83. 83 Identification and analysis of 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS) gene from glyphosate‐resistant Ochrobactrum intermedium Sq20 [DOI]
  84. 84 Reversibility of irreversible aging [DOI]
  85. 85 Parkinsonism Relating to Intoxication with Glyphosate [DOI]
  86. 86 Structural Imaging in Atypical Parkinsonism [DOI]
  87. 87 Examining Factors Related to Health-Related Quality of Life in People With Parkinson’s Disease [DOI]
  88. 88 The rise of glyphosate and new opportunities for biosentinel early‐warning studies [DOI]
  89. 89 “Zebrafish as an animal model for food safety research: trends in the animal research” [DOI]
  90. 90 Parkinsonian syndromes: A review [DOI]
  91. 91 Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson’s disease [DOI]
  92. 92 Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats [DOI]
  93. 93 The Aging Brain: Recent Research and Concepts [DOI]
  94. 94 Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model [DOI]
  95. 95 Nonmotor Symptoms in Vascular and Other Secondary Parkinsonism [DOI]
  96. 96 Etiology and Pathogenesis of Parkinson’s Disease [DOI]
  97. 97 Functional Architecture of the Cerebral Cortex [DOI]
  98. 98 Herbicides and Fungicides [DOI]
  99. 99 Parkinson's disease: A Review about Pathogenesis, Pharmaceutical Treatment and Experimental Models [DOI]
  100. 100 The effect of age and exercise on the proprioceptive and vestibular system [DOI]
  101. 101 Home visits: a strategy to improve newborn survival - Authors' reply [DOI]
  102. 102 Chapter 12: What does the Anthropocene hold for citizenship? [DOI]
  103. 103 Agriculture Development, Pesticide Application and Its Impact on the Environment [DOI]
  104. 104 Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications [DOI]
  105. 105 Risk of pesticide pollution at the global scale [DOI]
  106. 106 Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019 [DOI]
  107. 107 Pesticides and Soil Invertebrates: A Hazard Assessment [DOI]
  108. 108 Organophosphorus compounds and oximes: a critical review [DOI]
  109. 109 Brain Computer Interfaces for Improving the Quality of Life of Older Adults and Elderly Patients [DOI]
  110. 110 Organophosphorus pesticides: Impacts, detection and removal strategies [DOI]
  111. 111 Birth Rate Transition in the Republic of Korea: Trends and Prospects [DOI]
  112. 112 Characteristics of Neural Network Changes in Normal Aging and Early Dementia [DOI]
  113. 113 Subchronic exposure to a glyphosate-based herbicide causes dysplasia in the digestive tract of Wistar rats [DOI]
  114. 114 Peripheral vestibular system: Age-related vestibular loss and associated deficits [DOI]
  115. 115 Drug-induced Parkinsonism: A strong predictor of idiopathic Parkinson’s disease [DOI]
  116. 116 Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway [DOI]
  117. 117 Chitosan-Based Nanocomposites for Glyphosate Detection Using Surface Plasmon Resonance Sensor [DOI]
  118. 118 Oral ingestion of the environmental toxicant trichloroethylene in rats induces alterations in the gut microbiome: Relevance to idiopathic Parkinson's disease [DOI]
  119. 119 Agrotóxicos: os venenos ocultos na nossa mesa [DOI]
  120. 120 Drug-Induced Parkinsonism [DOI]
  121. 121 The Physiology of the Vestibular System [DOI]
  122. 122 Understanding Parkinson’s Disease (PD) in Ayurvedic Prospective [DOI]
  123. 123 Parkinson's disease in a worker exposed to insecticides at a greenhouse [DOI]
  124. 124 Effects of chemical fertilizer pesticides on human health [DOI]
  125. 125 The Journal of Neurosci [DOI]

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