Atrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012
Mohammed Al-Biltagi, Osama Tolba, Mohammed Elshanshory, Ibrahim Badraia, Sahar M. Hazaa
International Blood Research & Reviews · pp. 72–86 · Published 26 Aug 2013
10.9734/IBRR/2013/5220Abstract
Aims: is to correlate the atrial function with the level of oxidative stress marker (Glutathione) in children with Iron deficiency anemia (IDA). Materials and Methods: Thirty children with IDA and 20 healthy children had serum Ferritin, total blood Glutathione level and studied with conventional trans-thoracic 2-D echocardiography, Tissue Doppler (TDI) and Speckle Tracking Strain (STI) analysis. Study Design: A case–controlled study Place and Duration of Study: Pediatric Outpatient Clinic; Pediatric Hematology Unit; Pediatric Cardiology Unit; Pediatric Department; Faculty of Medicine; Tanta University Hospital; Egypt. The study was conducted between January; 2012 to December; 2012. Results: Children with IDA had significantly low Glutathione [4.63 ±3.4 ng/ml] (P =.013) and Ferritin [11.88 ±5.3 ng/ml] (P < .0001) levels than that observed in the control group. There was no significant increase in LA dimension and volume (minimum) [31± 27 ml] (P = .433), by M-mode but there was significant decrease in e/a ratio assessed by tissue Doppler in IDA patients [1.29 ±0.5] than in controls [1.6±0.7] (P = .038). There were significant decrease in LA velocity (P = .02) and increase in RA velocity (P = .04) compared to left atrial and atrial septal velocity and insignificant increase in left atrial velocity compared to atrial septal velocity. There was no significant correlation between Glutathione level and echo-Doppler parameters of atrial function (P >.05), but there was significant negative correlation between Hemoglobin% and atrial septal velocity (P < .05). Conclusion: IDA is associated with diastolic dysfunction. Tissue Doppler and STI were more sensitive than conventional echocardiography in detection of subclinical structural and functional changes due to hemodynamic abnormality in children with IDA.
References (46)
- 1 Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology [DOI]
- 2 Glutathione Metabolism and Its Implications for Health [DOI]
- 3 Hormones and Hemodynamics in Heart Failure [DOI]
- 4 Novel Speckle-Tracking Radial Strain From Routine Black-and-White Echocardiographic Images to Quantify Dyssynchrony and Predict Response to Cardiac Resynchronization Therapy [DOI]
- 5 Diastolic dysfunction and left atrial volume [DOI]
- 6 Severe Anemia in Malawian Children [DOI]
- 7 American Society of Echocardiography Recommendations for Quality Echocardiography Laboratory Operations [DOI]
- 8 Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage [DOI]
- 9 Two-Dimensional Speckle-Tracking Echocardiography of the Left Atrium: Feasibility and Regional Contraction and Relaxation Differences in Normal Subjects [DOI]
- 10 Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle [DOI]
- 11 Left Atrial Strain Predicts Reverse Remodeling After Catheter Ablation for Atrial Fibrillation [DOI]
- 12 Two-Dimensional Echocardiographic Methods for Assessment of Left Atrial Volume [DOI]
- 13 Feasibility of strain and strain rate imaging for the assessment of regional left atrial deformation: A study in normal subjects [DOI]
- 14 Adaptive response of the heart to long-term anemia induced by iron deficiency [DOI]
- 15 Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration [DOI]
- 16 Iron-deficiency anaemia enhances red blood cell oxidative stress [DOI]
- 17 Novel echocardiographic techniques to assess left atrial size, anatomy and function [DOI]
- 18 Iron status at 12 months of age — effects of body size, growth and diet in a population with high birth weight [DOI]
- 19 Left Atrial Stiffness Relates to Left Ventricular Diastolic Dysfunction and Recurrence After Pulmonary Vein Isolation for Atrial Fibrillation [DOI]
- 20 Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. [DOI]
- 21 High prevalence of atrial fibrosis in patients with dilated cardiomyopathy [DOI]
- 22 Physiologic aspects of anemia [DOI]
- 23 Atrial strain rate echocardiography can predict success or failure of cardioversion for atrial fibrillation: A combined transthoracic tissue Doppler and transoesophageal imaging study [DOI]
- 24 The effect of oxidative stress on human red cells glutathione peroxidase, glutathione reductase level, and prevalence of anemia among diabetics [DOI]
- 25 Glutathione loading prevents free radical injury in red blood cells after storage [DOI]
- 26 Oxidative status in iron‐deficiency anemia [DOI]
- 27 Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy: a two-dimensional speckle strain study [DOI]
- 28 Anaemia and the brain [DOI]
- 29 Iron Deficiency Anemia: A Call for Aggressive Diagnostic Evaluation [DOI]
- 30 Tissue Doppler echocardiography [DOI]
- 31 Tissue Doppler echocardiographic evidence of atrial mechanical dysfunction in coronary artery disease [DOI]
- 32 Association of anemia with diastolic dysfunction among patients with coronary artery disease in the Heart and Soul Study [DOI]
- 33 Effect of Age and Heart Rate on Atrial Mechanical Function Assessed by Doppler Tissue Imaging in Healthy Individuals [DOI]
- 34 The effects of iron deficiency anemia on p wave duration and dispersion [DOI]
- 35 Evaluation of cardiac functions with Doppler echocardiography in children with Down syndrome and anatomically normal heart [DOI]
- 36 A study on the effects of pica and iron-deficiency anemia on oxidative stress, antioxidant capacity and trace elements [DOI]
- 37 Role of oxidative stress and antioxidants in children with IDA.
- 38 A New Echocardiographic Formula to Calculate Ejection Fraction by Using Systolic Excursion of Mitral Annulus [DOI]
- 39 Limitations Inherent to the Simplified Bernoulli Equation Explain the Inaccuracy of Doppler Echocardiographic Estimates of Pulmonary Artery Pressures in Patients With Pulmonary Hypertension [DOI]
- 40 Echocardiographic findings in mild and severe forms of sickle cell anemia [DOI]
- 41 Glutathionyl Hemoglobin Is Elevated in Iron Deficiency Anemia [DOI]
- 42 [Reduced glutathione and porphobilinogen synthase activity in the erythrocytes of anemic patients with low serum iron].
- 43 Assessment of Cardiac Function in Iron-Deficient Children Without Anemia [DOI]
- 44 [The dynamics of left ventricular segmental diastolic function in patients with iron-deficit anemia treated within the course of treatment with sorbifer and triovit].
- 45 [Clinical and functional cardiac characteristics in iron-deficiency anemia].
- 46 Tissue Doppler Echocardiography [DOI]
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