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Research Article Open access CC BY 4.0

Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

Y. Davidkova, N. Simonoski, B. Spassov, G. Balatzenko, M. Guenova

International Blood Research & Reviews · pp. 28–33 · Published 24 Sep 2020

10.9734/ibrr/2020/v11i330132

Abstract

Bing-Neel syndrome is a rare neurologic complication of Waldenström’s macroglobulinemia, characterized by infiltration of the central nervous system by clonal lymphoplasmacytes. We present a rare clinical case of a patient, who one year after the diagnosis of Waldenström’s macroglobulinemia, progressed with diverse neurologic presentation and cerebrospinal fluid involvement. The diagnosis was based on magnetic resonance imaging and flow cytometry detection of clonal B-cells in the cerebrospinal fluid. Bing-Neel syndrome should be considered in patients with neurologic symptoms and a history of Waldenström’s macroglobulinemia.

Bing-Neel syndrome Waldenström’s macroglobulinemia orbital involvement cerebrospinal fluid.

References (7)

  1. 1 Overall survival and competing risks of death in patients with W aldenström macroglobulinaemia: an analysis of the S urveillance, E pidemiology and E nd R esults database [DOI]
  2. 2 Central nervous system involvement by Waldenström macroglobulinaemia (Bing‐Neel syndrome): a multi‐institutional retrospective study [DOI]
  3. 3 High‐dose therapy with autologous stem cells transplantation in Bing‐Neel syndrome: A retrospective analysis of 14 cases [DOI]
  4. 4 Orbital Involvement in Bing-Neel Syndrome [DOI]
  5. 5 Isolated Optic Nerve, Chiasm, and Tract Involvement in Bing–Neel Syndrome [DOI]
  6. 6 Bing–Neel Syndrome in a Patient with Waldenstrom's Macroglobulinemia: A Challenging Diagnosis in the Face of Normal Brain Imaging [DOI]
  7. 7 Late‐Onset Bing‐Neel Syndrome Associated with Delirium and Lewy Body Dementia [DOI]

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