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Research Article Open access CC BY 4.0

Case Report of Attenuated-Responsiveness to Coartem® in Western Kenya

Edwin Kamau, Hoseah M. Akala, Angela O. Achieng, Redemptah Yeda, Luicer A. Ingasia, Agnes C. Cheruiyot, Dennis W. Juma, Charles Okudo, Duke Omariba, Catherine Muriuki, Eunice A. Owiti, Patrick Omondi, Amos Otedo, Ben Andagalu, Bernhards Ogutu

International Journal of Medical and Pharmaceutical Case Reports · pp. 5–9 · Published 25 Sep 2014

10.9734/IJMPCR/2015/11141

Abstract

We describe a case of attenuated-responsiveness to Artemether-Lumefantrine (AL) in western Kenya. A 4-year old patient with 14% parasitemia was treated with Coartem® but on day 7 still had 5% parasitemia. Parasite genetic profile had similar genetic polymorphism as that selected for when AL is administered. In vitro analysis revealed elevated IC50s for AL components compared to the reference P. falciparum clone 3D7 and samples collected at this site over the last 5 years. There is need for continued global surveillance to effectively manage emergence and spread of artemisinin drug resistance which has now been found in Southeast Asia.

Coartem resistance Malaria artemether-lumefantrine treatment-failure.

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