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Research Article Open access CC BY 4.0

Coagulation Parameters among Individuals with Hepatitis B Infections in Okada, Edo State, Nigeria

Mitsan Olley, Sule Zekeri, Aghatise Kevin Erhamwonyi, Maureen Uchechukwu Okwu, Aiyanyor David Osayomwanbo, Osaiyuwu Osarenren Clement, Izevbuwa Osazee Ekundayo

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 44–49 · Published 20 Mar 2023

10.9734/jamps/2023/v25i1597

Abstract

Hepatitis B Viral (HBV) infection is a condition of inflammation of the liver. The Liver plays a vital role in the body which includes filtration of the blood, production of coagulation proteins and also as a storage organ. In this study, alteration of some coagulation parameters which include, Prothrombin time (PT), activated partial thromboplastin time (APTT), Platelets counts (PLATS) were determined in sixty (60) known seropositive individuals using standard haemostatic techniques. There was a significant reduction in the mean value (mean values) on platelet counts in the seropositive individuals (p- value) compared to the control group (mean value), also revealed in this study is an increase in the mean-time which was significant of PT among test individuals compared to seronegative controls individuals, there was an increase prothrombin time as well as Activated partial prothrombin time with both having p- values < 0.001. The average PT and APTT were 25.53 and 48.89 respectively. Individuals with Hepatitis B infection are thus liable to thrombocytopenia if not managed.

Coagulation parameters hepatitis b thrombocytopenia, fibronolysis

References (7)

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