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Research Article Open access CC BY 3.0

Design and Evaluation of Imatinib Mesylate Loaded Microspheres for Stomach Specific Drug Delivery

Rangasamy Manivannan, Bandaru Lakshmi Narayana Rao, Venkata Krishna Reddy

Journal of Pharmaceutical Research International · pp. 381–396 · Published 12 Dec 2013

10.9734/BJPR/2014/6444

Abstract

Aims: The aim of the present work was to design and evaluate the Imatinib mesylate microspheres using natural and semi synthetic polymers for stomach specific drug delivery. Study Design: Design and Evaluation of Imatinib Mesylate loaded microspheres Place and Duration of the Study: The study was carried out in Department of Pharmaceutics, JKKMMRF’s Annai JKK Sampoorani Ammal College of Pharmacy, between November 2012 and July 2013. Methodology: The microspheres were prepared using Sodium alginate as a polymer by Emulsification Ionic Gelation Technique. Copolymers of natural origin namely Guar gum, Karaya gum, Chitosan and semi synthetic origin namely Hydroxy propoylmethyl cellulose K4M, K15M, K100M are used as mucoadhesive polymers. The prepared microspheres were evaluated for their percentage yield, entrapment efficiency, degree of swelling, particle size, surface morphology and in-vitro mucoadhesion, drug release studies. Drug release kinetics was determined from drug release data. Selected formulations are subjected to stability studies under varying conditions of temperature and humidity. Results: The production yields of microspheres were found to be between 76.74 to 88.18%. Percentage drug entrapment efficiency of Imatinib mesylate microspheres was ranged from 65.51 to 88.78%. Particle size of the prepared microspheres was in the size range of 440-810µm. SEM analysis revealed that all the prepared microspheres were discrete, spherical in shape. The in-vitro mucoadhesive study demonstrated that Hydroxy propoylmethyl cellulose adhered to the mucus to a greater extent than other polymers. The in-vitro release study shows that, retarded release with increase in percentage of polymers. The release of drug from the microspheres followed Krosmeyer Peppas kinetics. After the stability studies, the formulations remained stable at the end of storage period. Conclusion: Based on the results, it was concluded that, the formulations with natural polymers were found to be best than semi synthetic polymers for the oral delivery of Imatinib mesylate.

Imatinib mesylate mucoadhesive microspheres Emulsification Ionic Gelation stomach specific delivery natural polymers semi synthetic polymers

References (9)

  1. 1 Mechanisms of solute release from porous hydrophilic polymers [DOI]
  2. 2 Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices [DOI]
  3. 3 A novel in situ method to test polymers and coated microparticles for bioadhesion [DOI]
  4. 4 Mucoadhesive Microspheres for Controlled Drug Delivery [DOI]
  5. 5 Formulation, and evaluation of pentoxifylline-loaded poly(ε-caprolactone) microspheres [DOI]
  6. 6 FORMULATION AND EVALUATION OF MICROSPHERES CONTAINING IMATINIB MESYLATE USING SODIUM ALGINATE BY CHEMICAL CROSS LINKING METHOD [DOI]
  7. 7 DEVELOPMENT OF RP-HPLC METHOD FOR THE ANALYSIS OF IMATINIB MESYLATE USING PDA DETECTOR AND ITS APPLICATION IN THE EVALUATION OF MARKETED PREPARATION
  8. 8 Indian Journal of Pharmaceutical Sciences [DOI]
  9. 9 International Journal of Research in Pharmacy and Chemistry [DOI]

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