Development, Characterization and Evaluation of Lactoferrin Conjugated and Memantine Loaded Peg-Plga Nanoparticles for the Treatment of Alzheimer's Disease
Rashi Jain, Virendra K. Sharma
Journal of Pharmaceutical Research International · pp. 492–497 · Published 29 Dec 2021
10.9734/jpri/2021/v33i63A36091Abstract
Alzheimer's disease is a degenerative neurological condition that has no cure and only a few treatment options. It has a negative impact on one's cognitive and behavioural abilities. Traditional medications, such as acetylcholinesterase inhibitors, are often ineffective because they do not penetrate the blood-brain barrier. Targeted therapy strategies involving nanoparticulate drug delivery devices have been employed to improve the efficacy of Alzheimer's disease treatment. Memantine is an Alzheimer's disease medicine that has been approved for the treatment of mild to moderate symptoms. To boost memantine's action at the target region, we employed a twofold emulsion technique to generate lactoferrin (Lf) combined with biodegradable PEG-PLGA nanoparticles (NPs). The average particle size of the synthesised NPs was 162.60.5 nm, with a polydispersity index of 0.1 and a surface charge of -21.5 mV. The crystalline drug was disseminated within the PLGA matrix, according to the physicochemical characterisation of NPs. During in vitro dissolution studies, the new nanoparticulate formulation displayed a sustained release profile of memantine. The NPs were noncytotoxic to brain cell lines, and bEnd.3 cells had a greater concentration of Lf-NP than unconjugated nanoparticles. The researchers discovered that Lf-conjugated PEG-PLGA nanoparticles carrying memantine are excellent for Alzheimer's disease targeted delivery.
References (23)
- 1 Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery [DOI]
- 2 Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization [DOI]
- 3 Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis [DOI]
- 4 Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease [DOI]
- 5 Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice [DOI]
- 6 Nanoparticles for Targeted Brain Drug Delivery: What Do We Know? [DOI]
- 7 Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease [DOI]
- 8 W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles [DOI]
- 9 Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases [DOI]
- 10 Surface modified PLGA nanoparticles for brain targeting of Bacoside-A [DOI]
- 11 Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer’s Disease in Mice [DOI]
- 12 Effect of PLGA NP size on efficiency to target traumatic brain injury [DOI]
- 13 Systemic delivery to central nervous system by engineered PLGA nanoparticles.
- 14 SYNTHESIS AND CHARACTERIZATION OF LIGAND ANCHORED POLY PROPYLENEIMINEDENDRIMERS FOR THE TREATMENT OF BRAIN GLIOMA [DOI]
- 15 Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model [DOI]
- 16 New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9 [DOI]
- 17 Design of Nanosuspensions and Freeze-Dried PLGA Nanoparticles as a Novel Approach for Ophthalmic Delivery of Pranoprofen [DOI]
- 18 Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine [DOI]
- 19 Design and elaboration of freeze-dried PLGA nanoparticles for the transcorneal permeation of carprofen: Ocular anti-inflammatory applications [DOI]
- 20 Efficacy and safety of memantine in patients with moderate-to-severe Alzheimer's disease: results of a pooled analysis of two randomized, double-blind, placebo-controlled trials in Japan [DOI]
- 21 SYNTHESIS AND CHARACTERIZATION OF TEMOZOLOMIDE LOADED THERANOSTIC QUANTUM DOTS FOR THE TREATMENT OF BRAIN GLIOMA [DOI]
- 22 Efficacy of memantine hydrochloride once-daily in Alzheimer’s disease [DOI]
- 23 A Review on Novel Techniques for Drug Delivery to the Brain
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