Disseminated Intravascular Coagulopathy; a Condition to Monitor in the Management of Leukaemia Patients
Olufemi E. Akanni, Bamisaye E. Oluwaseyi, Yusuf N. Olawale, AbdulAzeez Ibn AbdulAzeez, Njoku Azuka, Adetola Adebisi, Ajayi A. Olubunmi
Journal of Advances in Medicine and Medical Research · pp. 1–6 · Published 7 Jun 2018
10.9734/JAMMR/2018/40379Abstract
Background: Disseminated intravascular coagulopathy is a consumption coagulopathy which mostly results from an underlying disease. It occurs as a result of the activation of the coagulation cascade leading to the formation of thrombi which results in haemorrhage due to the excessive consumption of platelet and coagulation factors. Malignancy is associated with hypercoagulable state and increased risk for thrombohemorrhagic complications and leukaemia is no exception. Bleeding manifestations are common in acute leukemias, especially in acute myeloblastic leukemia, and are prominent features of an initial stage of the disease. This study assessed disseminated intravascular coagulopathy (DIC) in leukaemia patients in Nigeria. Materials and Methods: One hundred and sixteen (116) subjects consisting of 58 leukaemic subjects (AML, CLL, and CML) and 58 age and sex-matched healthy control subjects were recruited into the study. The parameters estimated in this study were packed cell volume (PCV), platelet count, white blood cell count (WBC), prothrombin time (PT), the international normalised ratio (INR), activated partial thromboplastin time (aPTT) and D-dimer assay. Results: The mean ± SD values of the parameters assessed in the leukaemia patients include 3.7±3.1 µg FEU/mL, 67.5±55.7 seconds, 1.8±0.1, 77.3±31.8 seconds, 194±103 cells/mm3, 74±124 cells/mm3, 30±5% for D-dimer, PT, INR, aPTT, platelets, WBC and PCV respectively. The results display a significant statistical difference between the leukaemic and the control subjects (p<0.05). Conclusion: The abnormality of these haemostatic parameters occurring in the leukaemic subjects (AML, CLL, and CML) is highly indicative of the occurrence of disseminated intravascular coagulopathy in these patients. This study, therefore, shows that disseminated intravascular coagulopathy can occur as a complication of various types of leukaemia studied and this requires prompt and appropriate management
Cited by 1
Bamisaye E. Oluwaseyi, Okungbowa A. Michael, Akanni E. Oluwafemi · Journal of Family Medicine and Primary Care · 2021
Related research
- Tumour Suppressive and Organ Protective Effects of Aqueous Andrographis paniculata Leaves Extract on Benzene Induced Leukaemia Bearing Rats — shares topic coverage
- African Polyherbal Formulation Possesses Chemopreventive and Chemotherapeutic Effects on Benzene- Induced Leukemia in Wistar Rats — shares topic coverage
- Expression of Evi-1 Gene in Leukaemia: Diagnostic and Prognostic Perspective — shares topic coverage
- Diagnostic Challenges in Hematological Malignancies in Nigeria and their Impact on Treatment Outcome — shares topic coverage
- Kigelia africana Stem Bark, Fruit and Leaf Extracts Alleviate Benzene-induced Leukaemia in Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
6
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.