Effect of Aqueous Extract of Guava (Psidium guajava) Leaf on Blood Glucose and Liver Enzymes in Alloxan Induced Diabetic Rats
Chioma Christiana Ogueri, Ify Elekwa, Victor Chibueze Ude, Amadike Eziuche Ugbogu
Journal of Pharmaceutical Research International · pp. 1079–1087 · Published 29 Mar 2014
10.9734/BJPR/2014/7244Abstract
Aim: The aim of this study is to determine the effect of aqueous extract of Psidium guajava leaf on blood glucose level and liver enzymes of alloxan –induced diabetic rat. Study Design: The animals were grouped into six of 6 rats each. Groups A, B, C and E were induced diabetes by intraperitoneal injection of alloxan monohydrate with a dose of 100mg/kg body weight. The extract was administered through gastric tube per kilogram body weight as follows: group A 200mg/kg, group B 150mg/kg, group C100mg/kg, group D none (normal control), group E none (untreated diabetic control) and group F150mg/kg (extract control). Methodology: Blood samples were collected by cardiac puncture after fasting overnight and standard methods were used for the extraction of spices, determination of fasting blood glucose and liver enzymes. Place and Duration of Study: The study was carried out at Abia State University Uturu-Nigeria and the entire experiments lasted between December 2011 and July 2012. Result: The results showed a significant (P<0.05) decrease in the blood glucose level compared to untreated diabetic control. There was no significant (P<0.05) difference observed in alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activity compared to all the controls (normal, untreated and extract control) while alanine aminotransferase (ALT) activity decreased significantly (P<0.05) compared to untreated diabetic control. Conclusion: Therefore, this result revealed that aqueous extract of Psidium guajava leaf possess anti-hyperglycemic properties with no side effect on selected liver enzymes compared to normal control and since the leaf did not show interference with functional integrity of the liver tissues it has a better potential for treatment of diabetes.
References (21)
- 1 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases [DOI]
- 2 National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants [DOI]
- 3 Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases [DOI]
- 4 Determination of blood glucose using 4-amino phenazone as oxygen acceptor. [DOI]
- 5 Textbook of Medical Physiology [DOI]
- 6 Diabetes Treatment — Bridging the Divide [DOI]
- 7 Quantitation of vitamin C content in herbal juice using direct titration [DOI]
- 8 Phytochemical and vitamin content of indigenous spices of South Eastern Nigeria
- 9 Inhibitory effects of guava (Psidium guajava L.) leaf extracts and its active compounds on the glycation process of protein [DOI]
- 10 Anti-Inflammatory and analgesic effects of Psidium guajava Linn. (myrtaceae) leaf aqueous extracts in rats and mice [DOI]
- 11 Effect of Aqueous Extract of Psidium Guajava Leaves on Liver Enzymes, Histological Integrity and Hematological Indices in Rats [DOI]
- 12 Biological Properties of Plant Flavonoids: An Overview [DOI]
- 13 Triterpenoids from the leaves of Psidium guajava [DOI]
- 14 Effect of Momordica charantia on Blood Glucose Level of Normal and Alloxan-Diabetic Rabbits [DOI]
- 15 Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats [DOI]
- 16 Antidiabetic activity of an ethanol extract obtained from the stem bark of Psidium guajava (Myrtaceae).
- 17 Effect of Guava ( Psidium guajava L.) Leaf Extract on Glucose Uptake in Rat Hepatocytes [DOI]
- 18 Phytochemical and antimicrobial activity of ethanolic extract of Landolphia owariensis leaf [DOI]
- 19 Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium [DOI]
- 20 Healthcare use for diarrhoea and dysentery in actual and hypothetical cases, Nha Trang, Viet Nam.
- 21 THE EFFECT OF FOETIDIN FROM MOMORDICA FOETIDA ON BLOOD GLUCOSE LEVEL OF ALBINO RATS [DOI]
Cited by 8
A. O. Ojetunde · Eastern Ukrainian Medical Journal · 2021
N. Atik, A. Amrullah, A. R. Rahmadi · 2018
Elixabet Díaz-de-Cerio, V. Verardo, A. Gómez-Caravaca · International Journal of Molecular Sciences · 2017
Anju Sati, B. Mondal, Ashok Kumar · 2020
Toluwani Tella, B. Masola, S. Mukaratirwa · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019
Elixabet Díaz de Cerio Alonso de Mezquía · 2017
Toluwani Tella · 2015
Showing 7 of 8 known citations — external sources report more than can currently be individually listed.
Related research
- Phytochemical Screening, In vitro Antioxidant Capacity and Nephro-protective Effects of Combined Extract of Psidium guajava and Carica papaya Leaves in Rats Intoxicated with Cadmium — shares topic coverage
- Effect of Sucrose and Boric Acid on in-vitro Pollen Germination of Guava (Psidium guajava) Varieties — shares topic coverage
- Antioxidant and Antimicrobial Activity of Psidium guajava (Pomifera and Pyrifera) Aqueous Leaf Extract Varieties’ — shares topic coverage
- Comparative Hypolipidaemic Effect of Aqueous Extract of Psidium guajava Leaves and Ascorbic Acid in Male Rats — shares topic coverage
- Proximate Analysis and Phytochemical Screening of Psidium guajava (Guava) and Cucumis sativus (Cucumber) Grown in Gashua Fadama Area of Yobe State, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
12
Page views
0
PDF downloads
0
Outbound clicks
8
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.