Efficacy of Different Doses of Oral Clonidine as Premedication in Attenuating Haemodynamic Response to Pneumoperitoneum in Patients During Laparoscopic Cholecystectomy
Saloni Mehta, Shaji Mathew, Suvajit Podder, Deepali Shetty
Journal of Pharmaceutical Research International · pp. 32–43 · Published 29 Aug 2023
10.9734/jpri/2023/v35i237421Abstract
Background: Laparoscopy procedures have gained an increasing demand over the years and rightly so due to its numerous advantages proving it superior to open surgeries. This is therefore important to all the anaesthesiologists to learn the physiological changes during laparoscopic surgery as well how to manipulate and blunt the hemodynamics as well. Methods: We have taken one such drug, an alpha agonist, oral clonidine and compared its 3 different doses to conclude the most efficacious and safe dosage amongst it. Results: 100 mcg dose of oral Clonidine is the most safest and most effective amongst the 3 doses of 50, 100 and 150 mcg. Conclusion: 1) Premedication with oral clonidine is a safe and effective method that provides haemodynamic stability against the neuroendocrine responses due to carboperitoneum in patients undergoing laparoscopic cholecystectomy. 2) Escalation of doses from 100 microgram to 150 microgram increases adverse effects and does not enhance efficacy.
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