Endothelial Dysfunction and Cardiovascular Disease: Critical Target for Cell-Based Therapies
Namita M. Varudkar, Heidi Emrani, Steven N. Ebert, Atul Madan
Journal of Advances in Medicine and Medical Research · pp. 3042–3058 · Published 13 Mar 2014
10.9734/BJMMR/2014/7329Abstract
This review briefly summarizes how cell-based therapeutic interventions are being developed and applied to treat endothelial dysfunction (ED) as a critical clinical target. ED directly contributes to the onset and prognosis for all of the major forms of cardiovascular diseases, including atherosclerosis, pulmonary artery hypertension, peripheral hypertension, stroke, myocardial infarction and congestive heart failure. Current pharmacological therapies used to treat ED are discussed and compared with newer strategies employing endothelial progenitor cells (EPCs) and other stem cells for tissue repair/regeneration therapies. Cell-based therapies to treat ED are still largely experimental but they are emerging in the clinic and represent a promising avenue for new interventional options to combat cardiovascular disease and improve patient outcomes.
Cited by 0
No indexed citations yet.
Related research
- Prognostic Value of Elevated Cardiac Troponin I Levels in Pre-dialysis Chronic Kidney Disease Patients without Cardiac Symptoms — shares topic coverage
- Risk Factors of Hypertension among Type 2 Diabetic Patients in Imo state, South East of Nigeria — shares topic coverage
- Patterns of Iron Biomarkers among Hypertensive Individuals in Yenagoa, Bayelsa State, Nigeria — shares topic coverage
- Levels of High Sensitivity C-reactive Protein and Albuminuria and Their Correlation in Hypertensive Patients in Southern Part of Nigeria — shares topic coverage
- Palm Oil: An Over - Acclaimed Cooking Oil in Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
6
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.