Establishing Standardized Procedure for the Administration of Anticoagulant Tablets via Nasogastric Tube: An In vitro Estimation by RP-HPLC

Abstract

Anticoagulant therapy required administration of the oral medications via an enteral feeding tube for the patient who is unable to consume orally. Anticoagulants are class of dosage form used in treatment of thrombotic disorders and to prolong the clotting time. In the proposed study, Edoxaban Tablets was crushed uniformaly to fine powder and suspended in desired vehicle to administer to the unconscious patient or who unable to swallow. Suspension was quantified for its recovery from the enternal feeding tube. Collected suspension from the enternal feeding tube was tested by the accurate RP-HPLC method for its Edoxaban content with recovery. Edoxaban is well resolve with C18 column using isocratic elution with acetonitrile and Triethylamine buffer (pH 5.5) with a flow rate of 1 mL/min appeared at retention time about 4 min and was quantified at its λmax (290 nm). It exhibited a accuracy and linearity over the concentration range of 14.910 µg/ml to 89.460 µg/ml of the test concentration. The procedure was developed and optimized for the paasing of suspension from the feeding tube to get recovery. The current work demonstrate the suspended form of drug with suitable vehicle can be administered to the unconscious patient and suitability of the procedure can be estimated by the validated method.