Estimation of Anti Inflammatory and Anti-Oxidant Property of Ethanolic Extract of Dialium guineense Stem Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Abstract

The hallmark of peptic ulcer illness is desisting in the gastrointestinal (GI) tract due to either pepsin or gastric acid release. It expands into the muscularis propria layer of the gastric epithelium. It may include the lower esophagus, distal duodenum or jejunum. The emergence and resistance of some over the counter anti-ulcer agents and its cost in developing countries have necessitate the need to optimize antiulcer actions of stem bark of Dialium guineense and its efficacy. The purpose of this study is to assess the anti-ulcerogenic properties of ethanol extract and stem bark fractions from Dialium guineense in albino rats that have been given an ethanol-induced ulcer. When compared to omeprazole and the fractions of the groups treated with 200 mg/kg, 400 mg/kg, and 500 mg/kg body weight of ethanol extract of Dialium guineense stem bark, the results of TNF-α, IL-β, and PGE2 revealed a substantial rise in the ulcer group. In GPx and CAT there were significant increase in normal control when compared to the ulcer group and different fractions, this findings showed that By enhancing the effectiveness of nicotineamide dinucleotide phosphate (NADPH) or by safeguarding the detoxifying enzymes, catalase lowers oxidative stress and lipid peroxidation. Further research should be on the identification of compounds which is responsible for the anti-inflammatory and antioxidant of Dialium guineense stem bark.