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Research Article Open access CC BY 4.0

Evaluating the Diagnostic and Prognostic Roles of Fibrinogen Degradation Products and C-reactive Protein in Management of Sickle Cell Disease

Amusan Festus

International Journal of Research and Reports in Hematology · pp. 209–214 · Published 13 Dec 2024

10.9734/ijr2h/2024/v7i2157

Abstract

Introduction: Abnormal hemoglobin is a hallmark of sickle cell disease (SCD), a genetic blood abnormality that can cause a number of clinical consequences, such as vaso-occlusive crises and an elevated risk of infection. One potential biomarker for evaluating disease activity and consequences in SCD patients is C-reactive protein (CRP), an acute-phase reactant that is frequently increased in inflammatory conditions. Aim/Objectives: The purpose of this study is to assess the diagnostic and prognostic value of FDP and CRP levels in sickle cell disease patients at the University College Hospital in Ibadan, Nigeria. Among the specific goals are measuring the levels of fibrinogen degradation products (FDP) and CRP in patients with sickle cell disease (SCD), figuring out how demographic characteristics like age and sex affect these measurements, and investigating the relationship between these parameters and clinical symptoms. Methods: There were 131 participants in the descriptive cross-sectional study, including 40 healthy controls and 91 persons with SCD diagnoses. Purposive random sampling was used to gather the data, and independent t-tests, correlation analysis, and descriptive statistics were used to analyze the results at a significance level of 5%. Results: The data suggested that 2.2% of SCD patients exhibited abnormal CRP levels. However, no significant difference was identified in mean CRP levels between SCD patients and healthy controls (p=0.400). However, there was a significant difference (p=0.001) in the mean FDP levels between the two groups. Furthermore, among SCD patients, no discernible relationships between CRP levels and sex or age were discovered. Conclusion: Fibrinogen degradation products levels are suggestive of thrombotic events in this population, whereas CRP levels may not differ substantially between SCD patients and healthy people. The findings imply that when it comes to addressing SCD complications, FDP monitoring may be more clinically useful than CRP. This emphasizes the necessity of more study to develop successful intervention plans based on these biomarkers in order to enhance patient outcomes.

Sickle cell disease C-reactive protein fibrinogen degradation products biomarkers prognosis hematology

References (15)

  1. 1 Inflammation in sickle cell disease [DOI]
  2. 2 C-reactive protein: a target for therapy to reduce inflammation [DOI]
  3. 3 C-reactive protein: structure, function, regulation, and role in clinical diseases [DOI]
  4. 4 C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation [DOI]
  5. 5 Biological significance of C-reactive protein, the ancient acute phase functionary [DOI]
  6. 6 C-reactive protein and disease outcome in Nigerian sickle cell disease patients [DOI]
  7. 7 Sickle cell disease in India: current status and progress [DOI]
  8. 8 Unmet Need: Mechanistic and Translational Studies of Sickle Cell Disease Pain as a Whole-Person Health Challenge [DOI]
  9. 9 Can we use biomarkers to identify those at risk of acute pain from sickle cell disease? [DOI]
  10. 10 Some markers of inflammation in patients with sickle cell disease at Zou-Collines departmental hospital in Benin [DOI]
  11. 11 C-reactive protein: issues of laboratory diagnostics [DOI]
  12. 12 C-Reactive Protein Levels in Adults With Sickle Cell Disease Visiting the University College Hospital, Ibadan, Nigeria [DOI]
  13. 13 C - reactive Protein Level and WBC Count as Biomarkers for Vaso-Occlusive Crisis among Patients with Sickle Cell Disease
  14. 14 A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell Anaemia [DOI]
  15. 15 Evaluating the Therapeutic Effects of Amino Acid Treatment on Vaso-Occlusive Pain in Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol v1 [DOI]

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