Evaluation of Cardiac Biomarkers in Detection of Cardiomyopathy Induced by Cardiotoxic Chemotherapeutic Agents
Subinay Datta, Mrinal Pal, Kaushik Ghosh, Ritabrata Mitra, Amit Kumar Pradhan
Journal of Cancer and Tumor International · pp. 196–205 · Published 28 Sep 2015
10.9734/JCTI/2015/19169Abstract
Background: Doxorubicin is a potent chemotherapeutic drug. The clinical usefulness of doxorubicin has been limited largely by the risk of cardiomyopathy and life-threatening heart failure. Therefore early identification of cardiotoxicity represents a primary goal for cardiologist and oncologist, considering the definition of personalized anticancer therapeutic strategies or intervention. The use of endomyocardial biopsy for detection of myocardial damage and monitoring of cardiac functions is troublesome in clinical practice. Aim: So, evaluation of different cardiac biomarkers was performed to specifically detect myocardial injury and to predict ventricular dysfunction. Methods: Fifty two adult AL patients (mean age 48.9±11.8 years, 25 males) treated with 2–6 cycles of chemotherapy (CT) containing cardiotoxic chemotherapeutic drugs were studied. Cardiac evaluation was performed at baseline, after first and last chemotherapy with cardiotoxic drugs and 6 months after chemotherapy. Results: Mean baseline NT-proBNP (N-terminal pro brain natriuretic peptide) concentration was 109.3±42.7 pg/ml (slightly elevated in 6 patients). After first and last chemotherapy, NT-proBNP elevations to 317.8±147.6 pg/ml and 302.3±123.9 pg/ml were observed, respectively. Six months after CT, mean NT-proBNP concentration was 412.5±184.2 pg/ml (elevated in 32 patients). Changes in NT-proBNP were significant in comparison with the baseline values (p < 0.001). Six months after chemotherapy, four patients with marked NT-proBNP elevations during chemotherapy developed treatment-related cardiomyopathy with symptoms of heart failure. NT-proBNP correlated with systolic and diastolic LV dysfunction on echocardiography (r = 0.638; p < 0.01) and (r = 0.412; p < 0.01). hs-cTnT concentrations were negative (<10 pg/ml) during chemotherapy in all patients. Six months after chemotherapy, delayed hs-cTnT positivity occurred in 6 patients. CK-MB mass remained within the reference range in all patients. Conclusion: The present study suggests that NT-proBNP in blood is better indicator for the detection of doxorubicin induced cardiotoxicity during the treatment and the follow-up than hs-cTnT, cTnI and CK-MB.
References (21)
- 1 Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity [DOI]
- 2 Doxorubicin: The Good, the Bad and the Ugly Effect [DOI]
- 3 Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy [DOI]
- 4 Cardiotoxicity of Chemotherapeutic Agents [DOI]
- 5 The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease [DOI]
- 6 N-Terminal Pro-B-Type Natriuretic Peptide after High-Dose Chemotherapy: A Marker Predictive of Cardiac Dysfunction? [DOI]
- 7 Late anthracycline cardiotoxicity after childhood cancer [DOI]
- 8 Correlation Between Serum Levels of Cardiac Troponin-T and the Severity of the Chronic Cardiomyopathy Induced by Doxorubicin [DOI]
- 9 Doxorubicin-Induced Cardiac Toxicity [DOI]
- 10 Elevated B-type natriuretic peptide levels after anthracycline administration [DOI]
- 11 Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies [DOI]
- 12 Review of Tests for Monitoring Doxorubicin-lnduced Cardiomyopathy [DOI]
- 13 B-Type Natriuretic Peptide — A Window to the Heart [DOI]
- 14 Natriuretic peptides as markers of cardiotoxicity during doxorubicin treatment for non‐Hodgkin's lymphoma [DOI]
- 15 Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m2) cyclophosphamide [DOI]
- 16 Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy [DOI]
- 17 Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats [DOI]
- 18 In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity [DOI]
- 19 Atrial natriuretic peptide as a marker for doxorubicin-induced cardiotoxic effects [DOI]
- 20 The Measurement of Cardiac Markers [DOI]
- 21 Cardiac Troponin T Following Anthracycline Chemotherapy in Children and Adolescents [DOI]
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