Evaluation of Oxidative Stress in Liver Cirrhosis Patients to Early Diagnosis of Minimal Hepatic Encephalopathy
K. P. Sangeetha, Narayanasamy Krishnasamy, K. Padma, Karthick Rajendran
International Neuropsychiatric Disease Journal · pp. 1–9 · Published 19 Oct 2015
10.9734/INDJ/2016/19004Abstract
Introduction: Minimal hepatic encephalopathy (MHE) is mildest form of the spectrum of neuropsychiatric and neurocognitive impairment in cirrhosis. Early recognition of this impairment may prevent the progression or may delay the development of the disease to overt hepatic encephalopathy. Although certain evidence suggest that that oxidative stress is a central component in the pathogenesis MHE, data remain controversial. Aims: We tested the utility of glutathione peroxidase (GPx) as an oxidative stress marker of HE by comparing its levels in patients with MHE. Study Design: The study was conducted in 60 subjects, included 30 cirrhotic patients (19 with MHE, 11 without MHE) and 30 control subjects. Results: Cirrhosis patients with signs of MHE had decreased levels of GPx when compared to the Non-MHE and control groups. Our study provided evidence of increased oxidative stress in patients affected with MHE, as expressed by decreased serum glutathione peroxidase antioxidant. We also found a significant negative correlation between the levels of serum glutathione peroxidase antioxidant and Child-Turcotte-Pugh (CTP) score (r = -0.734, P = .0001). Conclusion: Our findings revealed that the levels of the oxidative stress marker - GPx, may contribute to early diagnosis of MHE when used in conjunction with other routine markers.
References (22)
- 1 Mitochondrial Glutathione, a Key Survival Antioxidant [DOI]
- 2 Correlation between ammonia levels and the severity of hepatic encephalopathy [DOI]
- 3 Interaction among vitamin C, vitamin E, and beta-carotene [DOI]
- 4 Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy [DOI]
- 5 The prognostic significance of subclinical hepatic encephalopathy [DOI]
- 6 Superoxide Production and Antioxidant Enzymes in Ammonia Intoxication in Rats [DOI]
- 7 The importance of redox state in liver damage [DOI]
- 8 Minimal hepatic encephalopathy matters in daily life [DOI]
- 9 Blood ammonia levels in liver cirrhosis: a clue for the presence of portosystemic collateral veins [DOI]
- 10 The neurological disorder associated with liver disease.
- 11 Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication [DOI]
- 12 Blood Ammonia Levels and Hepatic Encephalopathy [DOI]
- 13 Sources of oxygen radicals in brain in acute ammonia intoxication in vivo [DOI]
- 14 Oxidative stress in the development of liver cirrhosis: A comparison of two different experimental models [DOI]
- 15 Determination of ammonia concentrations in cirrhosis patients-still confusing after all these years? [DOI]
- 16 Level of oxidative stress in the red blood cells of patients with liver cirrhosis.
- 17 Increase of Resting Levels of Superoxide Anion in the Whole Blood of Patients With Decompensated Liver Cirrhosis [DOI]
- 18 Monitoring oxidative stress across worsening child pugh class of cirrhosis [DOI]
- 19 An in vitro model for analysis of oxidative death in primary mouse astrocytes [DOI]
- 20 The prognostic significance of subclinical hepatic encephalopathy [DOI]
- 21 Hepatic encephalopathy forward to the past [DOI]
- 22 Alcohol and Acetaminophen Hepatotoxicity [DOI]
Cited by 10
I V Damulin · Terapevticheskii arkhiv · 2018
Chia-Yu Lai, Shao-Bin Cheng, Teng-Yu Lee · Nutrients · 2020
Anna Licata, Maddalena Zerbo, Silvia Como · Nutrients · 2021
Wilfred Ashwin, Reka Deva, Chandrashekaran Girish · World Journal of Meta-Analysis · 2025
A. Khelfi, A. Mahmoud, S. Perrone · Biomarkers of Oxidative Stress · 2024
Showing 5 of 10 known citations — external sources report more than can currently be individually listed.
Related research
- Salivary Lipid Peroxidation and Antioxidant Status in Nigerian Cigarette Smokers with or Without Periodontitis — shares topic coverage
- Profile of Biochemical and Oxidative Stress Markers in Male Athletes Following Strenuous Exercise Session — shares topic coverage
- Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Ebselen a Seleno-organic Molecule Inhibits Alteration in the Biological Responses in Hypoxic Human Alveolar Lung Epithelial Cells — shares topic coverage
Article metrics
Real usage data collected on this platform.
16
Page views
0
PDF downloads
9
Outbound clicks
10
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.