Evaluation of the Protective Potential of Chromolaena odorata Linn. Extract on Carbon Tetrachloride-Induced Oxidative Liver Damage
Chinwe Sylvanus Alisi, Geoffrey Okike C. Onyeze, Okey Alphonsus Ojiako, Chidi G. Osuagwu
International Journal of Biochemistry Research & Review · pp. 69–81 · Published 19 Jul 2011
10.9734/IJBCRR/2011/406Abstract
Carbon tetrachloride and its toxic metabolites consistently produce liver injury in many species including man. The hepatoprotective potential of Chromolaena odorata Linn. (C. odorata) was evaluated in male rabbits against carbon tetrachloride-induced liver damage. Carbon tetrachloride intoxicated control (CCl4) and ethanol extract of C. odorata-treated rabbits (ETECO TEST) received a single dose of CCl4 (0.2 ml/kg bw in liquid paraffin 1:1). Pre-treated rabbits received ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg/kg in morning and at night for 6 days prior to CCl4 administration. Sylimarin control received 50 mg/kg bw as a replacement for ETECO prior to CCl4 intoxication. Normal animals received only extract in the above stated dose and served as extract controls (ETECO CTRL). Pre-treatment with C. odorata significantly (p<0.05) prevented the elevation of serum aspartate aminotransferase (AST), alanineaminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (×¥-GT), total bilirubin and malondialdehyde (MDA) resulting from carbon tetrachloride intoxication. C. odorata extract also significantly (p<0.05) prevented a decrease in serum total protein, albumin, and glutathione (GSH) concentrations. The extract also significantly (p<0.05) prevented a decrease in superoxide dismutase (SOD), catalase (CAT) and glutathione-s-transferase (GST) activities. The presence of secondary plant metabolites like alkaloids, saponins, phenolic compouds, flavonoids and tannins found in C. odorata extract could be responsible for its hepatoprotective action.
Cited by 28
Chinwe S. Alisi, Samuel E. Abanobi · International Journal of TROPICAL DISEASE & Health · 2012
Precious Nc. Alisi, F. I. Buseri, Chinwe S. Alisi · International Blood Research & Reviews · 2014
O. Oladejo, S. O. Dahunsi, E. L. Odekanle · Cleaner Engineering and Technology · 2025
H. Yusuf, Hijra Novia, M. Fahriani · Narra J · 2023
A. Majekobaje, Segun M. Adeyemo, O. Y. Ogunsanwo · European Journal of Agriculture and Food Sciences · 2022
C. Aboyeji, D. O. Olaniyan, O. Dunsin · Plant Physiology Reports · 2021
Ngoc-Dung Huynh Luu, Le Dang, Hoàng Minh Bùi · Journal of nanomaterials · 2021
A. Tiamiyu, O. Okunlade · 2020
Mba-Omeje Nkechinyere, Ossai-Oloto Mary Chioma · American Journal of Biomedical and Life Sciences · 2020
E. C. Woko, C. Ibegbulem, C. Alisi · bioRxiv · 2020
Showing 25 of 28 known citations — external sources report more than can currently be individually listed.
Related research
- Salivary Lipid Peroxidation and Antioxidant Status in Nigerian Cigarette Smokers with or Without Periodontitis — shares topic coverage
- Profile of Biochemical and Oxidative Stress Markers in Male Athletes Following Strenuous Exercise Session — shares topic coverage
- Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Ebselen a Seleno-organic Molecule Inhibits Alteration in the Biological Responses in Hypoxic Human Alveolar Lung Epithelial Cells — shares topic coverage
Article metrics
Real usage data collected on this platform.
95
Page views
0
PDF downloads
8
Outbound clicks
28
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.