Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation
Bazigha K. Abdul Rasool, Oday S. Azeez, Hamda A. Lootah, Iman M. Abusharbain, Hiba A. Abu-Alhaj, Fazilatun Nessa
Journal of Pharmaceutical Research International · pp. 2494–2510 · Published 24 Oct 2014
10.9734/BJPR/2014/13723Abstract
This study aimed at the investigation of piroxicam-niosomal hydrogel for ocular targeting to prolong and enhance its local analgesic activity. Various formulations were prepared, characterized and evaluated ex vivo for their transocular permeation using excised cow cornea. The prepared niosomes had distinct spherical multi-lamellar shape and mean vesicle size between 1.25±0.81μm and 7.47±0.85μm. Relevant increase in drug EE% was obtained with increase of cholesterol content and surfactant’s hydrophobicity. Drug retention in vesicles was significantly (p<0.05) higher at refrigerated condition than that at the room temperature. Prolonged drug release was achieved with high niosomal cholesterol content and the mechanism of drug release can be described as Fickian diffusion. The niosomal hydrogel showed 3.7 Permeability Improvement Ratio comparing to piroxicam aqueous suspension. The optimized niosomal gel showed prolonged drug release and enhanced piroxicam ocular bioavailability due to the formation of an amorphous drug form within the gel.
References (26)
- 1 Mechanisms of solute release from porous hydrophilic polymers [DOI]
- 2 Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices [DOI]
- 3 Dependence of Reaction Velocity upon surface and Agitation [DOI]
- 4 Non-ionic surfactant based vesicles (niosomes) in drug delivery [DOI]
- 5 The use of mucoadhesive polymers in ocular drug delivery [DOI]
- 6 The preparation and properties of niosomes—non-ionic surfactant vesicles [DOI]
- 7 Corneal Penetration Behavior of β-Blocking Agents I: Physicochemical Factors [DOI]
- 8 Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide [DOI]
- 9 Liposomes as an ocular delivery system for acetazolamide: In vitro and in vivo studies [DOI]
- 10 Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery [DOI]
- 11 The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice [DOI]
- 12 Penetration Enhancers and Ocular Bioadhesives: Two New Avenues for Ophthalmic Drug Delivery [DOI]
- 13 Studies in topical application of niosomally entrapped Nimesulide.
- 14 Formulation and evaluation of Ketoconazole niosomal gel drug delivery system [DOI]
- 15 Quantitative Calculations in Pharmaceutical Practice and Research
- 16 A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. [DOI]
- 17 Lidocaine-loaded non-ionic surfactant vesicles: characterization and in vitro permeation studies [DOI]
- 18 Discoidal niosome based controlled ocular delivery of timolol maleate.
- 19 VESICULAR DRUG DELIVERY SYSTEMS: A NOVEL APPROACH FOR DRUG TARGETING
- 20 A rapid and sensitive method for simultaneous determination of insulin and A21-desamido insulin by high-performance liquid chromatography [DOI]
- 21 Non-ionic surfactant vesicles as ophthalmic carriers for cyclopentolate. A preliminary evaluation
- 22 In vitro transcorneal permeation of ketorolac tromethamine from buffered and unbuffered aqueous ocular drops.
- 23 Effect of pH and Formulation Variables on In Vitro Transcorneal Permeability of Flurbiprofen: A Technical Note [DOI]
- 24 Effectiveness and Tolerance of Piroxicam 0.5% and Diclofenac Sodium 0.1% in Controlling Inflammation after Cataract Surgery [DOI]
- 25 An evaluation of factors affecting the in vitro bioassay for erythropoietin.
- 26 Development and Targeting Efficiency of Irinotecan Engineered Proniosomes [DOI]
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