Flavonol Glycosides from the Aerial Parts of Indigofera hirsuta and Anti-inflammatory Activity of n-butanol Fraction
L. S. Abbas, A. M. Musa, M. I. Abdullahi, M. G. Magaji, M. I. Sule, B. Bawa
Journal of Pharmaceutical Research International · pp. 897–905 · Published 15 Aug 2013
10.9734/BJPR/2013/3609Abstract
Aims: The study aimed to phytochemically investigate the n-butanol soluble fraction of Indigofera hirsuta aerial parts and to evaluate the anti-inflammatory activity of the fraction using laboratory animal models. Study Design: Isolation and elucidation of the bioactive compounds and anti-inflammatory activity investigation on n-butanol soluble fraction. Place and Duration of Study: Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria - Nigeria. The study was completed between January-October, 2011. Methodology: The compounds isolated were identified using different spectroscopic techniques. The n-butanol fraction was investigated for its effect on carrageenan-induced oedema in rat’s experimental model. Results: Two Flavonol glycosides were isolated; Kaempferol-3-O-β-D-glucopyranoside (T2) and Kaempferol-7-O-β-D-glucopyranoside (Q3).The fraction significantly (P = .05) inhibited the carrageenan-induced paw oedema at doses of 150 and 300 mg/kg tested. The percentage anti-inflammatory effect of the highest dose tested (300 mg/kg) at the peak hour was higher than that of ketoprofen (10 mg/kg), the standard anti-inflammatory agent. Conclusion: The result of this research suggests that the n-butanol soluble fraction of Indigofera hirsuta aerial parts contains bioactive compounds with anti-inflammatory activity.
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