Formulation, Development and Evaluation of Ibuprofen Loaded Nano-transferosomal Gel for the Treatment of Psoriasis
Marwa H. Abdallah, Amr S. Abu Lila, Md. Khalid Anwer, El-Sayed Khafagy, Muqtader Mohammad, Mahmoud S. Soliman
Journal of Pharmaceutical Research International · pp. 1–8 · Published 21 Dec 2019
10.9734/jpri/2019/v31i630356Abstract
The present work was aimed to develop a transferosomal gel of ibuprofen (IBU) for the amelioration of psoriasis like inflammation. Three formulation of IBU loaded transferosomes (TFs1-TFs3) were prepared using different proportions of lipid (phospholipon 90H) and surfactant (tween 80) and further evaluated for vesicle size, zeta potential (ZP), entrapment efficiency and in vitro drug release. The IBU loaded transferosomes (TFs2) was optimized with vesicle size (217±8.4 nm), PDI (0.102), ZP (-31.5±4.3 mV), entrapment efficiency (88.4±6.9%) and drug loading (44.2±2.9%). Further, the optimized IBU loaded transferosomes (TFs2) was incorporated into 1% carbopol 934 gel base and characterized for homogeneity, extrudability, viscosity and drug content. The in vivo pharmacodynamic study of gel exhibited reduction in psoriasis like inflammation in mice. The ibuprofen loaded transferosomal gel was successfully developed and has shown the potential to be a new therapy against psoriasis like inflammation.
References (13)
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Cited by 42
Marwa H. Abdallah, Hemat El-Sayed El-Horany, Hanan M. El-Nahas · Pharmaceutics · 2023
Syeda Nashvia Adin, Isha Gupta, Mohd. Aqil · Journal of Drug Targeting · 2025
Marwa H. Abdallah, Mona M. Shahien, Alia Alshammari · Gels · 2024
Abdullah S Alshetaili, Salman Almohizea, Md. Khalid Anwer · Journal of the Science of Food and Agriculture · 2024
Marwa H. Abdallah, Hanaa A. Elghamry, Nasrin E. Khalifa · Gels · 2022
Marwa H. Abdallah, Mona M. Shahien, Hemat El-Sayed El-Horany · Gels · 2025
Marwa Abdallah, Seham Shawky, Mona Shahien · International Journal of Nanomedicine · 2024
Mohammed Ghazwani, Mohammed H. Alqarni, Umme Hani · International Journal of Molecular Sciences · 2023
Sameer J. Nadaf, Suresh G. Killedar · Nanoscale Processing · 2021
Marwa H. Abdallah, Dina M. Abdelnabi, Hanaa A. Elghamry · Gels · 2022
Showing 20 of 42 known citations — external sources report more than can currently be individually listed.
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