Formulation, Development and Evaluation of Ibuprofen Loaded Nano-transferosomal Gel for the Treatment of Psoriasis
Marwa H. Abdallah, Amr S. Abu Lila, Md. Khalid Anwer, El-Sayed Khafagy, Muqtader Mohammad, Mahmoud S. Soliman
Journal of Pharmaceutical Research International · pp. 1–8 · Published 21 Dec 2019
10.9734/jpri/2019/v31i630356Abstract
The present work was aimed to develop a transferosomal gel of ibuprofen (IBU) for the amelioration of psoriasis like inflammation. Three formulation of IBU loaded transferosomes (TFs1-TFs3) were prepared using different proportions of lipid (phospholipon 90H) and surfactant (tween 80) and further evaluated for vesicle size, zeta potential (ZP), entrapment efficiency and in vitro drug release. The IBU loaded transferosomes (TFs2) was optimized with vesicle size (217±8.4 nm), PDI (0.102), ZP (-31.5±4.3 mV), entrapment efficiency (88.4±6.9%) and drug loading (44.2±2.9%). Further, the optimized IBU loaded transferosomes (TFs2) was incorporated into 1% carbopol 934 gel base and characterized for homogeneity, extrudability, viscosity and drug content. The in vivo pharmacodynamic study of gel exhibited reduction in psoriasis like inflammation in mice. The ibuprofen loaded transferosomal gel was successfully developed and has shown the potential to be a new therapy against psoriasis like inflammation.
References (13)
- 1 Psoriasis Severity and the Prevalence of Major Medical Comorbidity [DOI]
- 2 An Overview of Clinical Pharmacology of Ibuprofen [DOI]
- 3 Lipid-based nano-delivery systems for skin delivery of drugs and bioactives [DOI]
- 4 Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation [DOI]
- 5 Apremilast: A Review in Psoriasis and Psoriatic Arthritis [DOI]
- 6 Comprehensive review on additives of topical dosage forms for drug delivery [DOI]
- 7 Niosomes in sustained and targeted drug delivery: some recent advances [DOI]
- 8 Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats [DOI]
- 9 Treatment Approaches to Moderate to Severe Psoriasis [DOI]
- 10 Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation [DOI]
- 11 Development and optimization of ketoconazole loaded nano-transfersomal gel for vaginal delivery using Box-Behnken design: In vitro , ex vivo characterization and antimicrobial evaluation [DOI]
- 12 PREPARATION AND CHARACTERIZATION OF IBUPROFEN LOADED TRANSFEROSOME AS A NOVEL CARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM
- 13 Enhanced Oral Bioavailability of Ibuprofen in Rats by Poloxamer Gel Using Poloxamer 188 and Menthol [DOI]
Cited by 42
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Marwa H. Abdallah, Mona M. Shahien, Hemat El-Sayed El-Horany · Pharmaceuticals · 2024
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