Free Radical Scavenging and In-vitro Antioxidant Effects of Ethanol Extract of the Medicinal Herb Chromolaena odorata Linn.
C. S. Alisi, O. A. Ojiako, C. G. Osuagwu, G. O. C. Onyeze
Journal of Pharmaceutical Research International · pp. 141–155 · Published 23 Jul 2011
10.9734/BJPR/2011/409Abstract
The ethanol extract of the leaf of Chromolaena odorata (Linn) was assessed for free-radical-scavenging and antioxidant potentials. Ability of the extract to scavenge reactive intermediates (superoxide ion O2·-, hydrogen peroxide H2O2, nitric oxide NO˙, hydroxyl radical OH˙) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, were used to assess its free radical scavenging potentials. Antioxidant potential was studied by assessing in-vitro inhibition of lipid peroxidation in both the brain (Neuro-protective potentials) and liver homogenates of Fenton-oxidant stressed rabbits. Inhibition of protein oxidation was assessed in-vitro by loss of protein thiol (P-SH), while assessment of the reducing power of the extract was further used to assess antioxidant capacity. Results obtained showed the ability of the extract to scavenge free radicals and reactive intermediates in a dose-response manner. The plant also had good antioxidant capacity. The secondary plant metabolites found earlier in the extract may explain reasons for the bio-efficacy of the plant. These findings are of great importance in view of the availability of the plant and its observed possible diverse applications in medicine and nutrition.
References (46)
- 1 An Algorithm for Least-Squares Estimation of Nonlinear Parameters [DOI]
- 2 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction [DOI]
- 3 Free radicals and antioxidants in normal physiological functions and human disease [DOI]
- 4 Superoxide Dismutase [DOI]
- 5 Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. [DOI]
- 6 Metals, Toxicity and Oxidative Stress [DOI]
- 7 Antioxidant properties of phenolic compounds [DOI]
- 8 Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury [DOI]
- 9 The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids [DOI]
- 10 Biochemistry and pathology of radical-mediated protein oxidation [DOI]
- 11 Free Radical Mechanisms in Tissue Injury [DOI]
- 12 Free-radical mechanisms in tissue injury [DOI]
- 13 Phenolics as potential antioxidant therapeutic agents: Mechanism and actions [DOI]
- 14 Kinetics and Mechanisms of Antioxidant Activity using the DPPH.Free Radical Method [DOI]
- 15 Review: Methods Used to Evaluate the Free Radical Scavenging Activity in Foods and Biological Systems [DOI]
- 16 Oxidants and human disease: some new concepts 1 [DOI]
- 17 Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk [DOI]
- 18 Protein Oxidation [DOI]
- 19 LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY [DOI]
- 20 Antioxidants and Human Disease: A General Introduction [DOI]
- 21 Antioxidants in food and food antioxidants [DOI]
- 22 Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N ‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration [DOI]
- 23 Lipid peroxidation and cellular damage in toxic liver injury.
- 24 Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions1This study is dedicated to the memory of Botany Professor Luiz F.G. Labouriau (1921–1996).1 [DOI]
- 25 Antioxidant and free radical scavenging potential of Achillea santolina extracts [DOI]
- 26 Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica [DOI]
- 27 The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer [DOI]
- 28 Scavenging of reactive-oxygen species and DPPH free radicals by extracts of borage and evening primrose meals [DOI]
- 29 Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing. [DOI]
- 30 Antioxidant activity of Paraguayan plant extracts [DOI]
- 31 Flavonoids and Breast Cancer Risk in Italy [DOI]
- 32 Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo [DOI]
- 33 Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats [DOI]
- 34 [38] Protein oxidative damage [DOI]
- 35 The effect of oxygen‐derived free radicals on gingival proteoglycans and hyaluronic acid [DOI]
- 36 Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine–xanthine oxidase induced damage [DOI]
- 37 Antioxidant Activity of Phenolic Compounds Isolated from Mesona procumbens Hemsl. [DOI]
- 38 Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide [DOI]
- 39 Antiparkinson drug – Mucuna pruriens shows antioxidant and metal chelating activity [DOI]
- 40 Endothelial Dysfunction in Normal and Abnormal Glucose Metabolism [DOI]
- 41 Antioxidant action of Guilingji in the brain of rats with FeCl3-induced epilepsy [DOI]
- 42 Nitric oxide scavenging ability of ethyl acetate fraction of methanolic leaf extracts of Chromolaena odorata (Linn.) [DOI]
- 43 Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.
- 44 Inhibitory Effects of Plant-Derived Flavonoids and Phenolic Acids on Malonaldehyde Formation from Ethyl Arachidonate [DOI]
- 45 Antibiotic Properties of Ethanol Extract of Chromolaena odorata (Asteriaceae) [DOI]
- 46 Handbook of African medicinal plants [DOI]
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