Genotoxicity in Neuro Degenerative and Neuropsychiatric Diseases: A Review
Chayanika Talukdar, Ashoka Babu VL
Current Journal of Applied Science and Technology · pp. 167–177 · Published 19 May 2025
10.9734/cjast/2025/v44i54546Abstract
The research investigates how genotoxicity drives the development of diseases that affect the nervous system as well neuropsychiatric conditions. This phenomenon shows that neuronal cells experience increased sensitivity to genomic harm partly because of their elevated metabolic activity together with restricted DNA repair mechanisms. The total DNA damage combination with increased oxidative pressure and impaired mitochondria causes Alzheimer's disease as well as Parkinson's disease and schizophrenia. Pollutants and heavy metals increase psychiatric disorder risks when combined with genotoxic stress in the body which leads to neurodegeneration. The evaluation stresses the need to comprehend how DNA damage and repair functions work in biology because therapeutic methods which lower oxidative stress and boost DNA repair should provide better treatments for cognitive decline and brain health.
Cited by 0
No indexed citations yet.
Related research
- Salivary Lipid Peroxidation and Antioxidant Status in Nigerian Cigarette Smokers with or Without Periodontitis — shares topic coverage
- Profile of Biochemical and Oxidative Stress Markers in Male Athletes Following Strenuous Exercise Session — shares topic coverage
- Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Ebselen a Seleno-organic Molecule Inhibits Alteration in the Biological Responses in Hypoxic Human Alveolar Lung Epithelial Cells — shares topic coverage
Article metrics
Real usage data collected on this platform.
5
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.