Hepatoprotective Effects of Talinum Triangulare Aqueous Extract on Paracetamol-Induced Liver Damage in Wistar Rats: A Histomorphological Study

Abstract

Background and Aim: Many vital bodily processes are carried out by the liver, and if it develops a disease, those processes may cease, which might seriously affect the function of the body. Talinum triangulare has been documented to possess hepato-protective, antioxidant and anti-inflammatory activities. This study aims to evaluate the potential of Talinum triangulare aqueous extract in protecting and repairing liver damage induced by paracetamol through histomorphological analysis in Wistar rats. Methods: Thirty-five Wistar rats were divided into five groups: a negative control, a positive control (paracetamol only), and three treatment groups receiving paracetamol followed by 100, 200, or 300 mg/kg body weight of T. triangulare extract for seven days. The experiment lasted for 14 days. Results: Histomorphological examination showed significant liver deterioration in the untreated group (Group 2), whereas Groups 3, 4, and 5 treated with Talinum triangulare extract exhibited notable recovery. There was reduced necrosis, inflammation and improved hepatocyte regeneration. Conclusion: The findings indicate that T. triangulare extract exhibits significant hepatoprotective effects, suggesting its potential as a natural remedy for managing paracetamol-induced liver injuries. Significance: The result from this study will create more awareness on the need to avoid the abuse of paracetamol.