Hypocholesterolemia and Statins in Multiple Myeloma
Irfan Yavasoglu, Atakan Turgutkaya
International Blood Research & Reviews · pp. 8–10 · Published 10 Aug 2021
10.9734/ibrr/2021/v12i430156Abstract
Statins are lipid-lowering agents. They also have immunomodulatory, anti-inflammatory, anti-angiogenic, and anti-proliferative functions. In this context, they are demonstrated to have beneficial effects on mortality in several malignancies including esophageal, breast, lung, liver, pancreatic, endometrial, and colorectal cancers. Multiple myeloma is considered as an incurable plasma cell disorder with current therapy; however due to the current knowledge about the correlation between cholesterol-lowering agents and myeloma; it’s suggested to have lower mortality rates for patients using statins. Patients with multiple myeloma usually have a low cholesterol level which is often underestimated by clinicians. Hereby we aimed to summarize the myeloma-hypocholesterolemia relationship and emphasize the importance of statins as an inexpensive and beneficial approach for these patients.
References (8)
- 1 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells [DOI]
- 2 Statins Are Associated With Reduced Mortality in Multiple Myeloma [DOI]
- 3 Statin use is associated with improved survival in multiple myeloma: A Swedish population‐based study of 4315 patients [DOI]
- 4 Cholesterol levels in patients with multiple myeloma [DOI]
- 5 Dose-finding study of high-dose simvastatin combined with standard chemotherapy in patients with relapsed or refractory myeloma or lymphoma.
- 6 High dose Simvastatin does not reverse resistance to Vincristine, Adriamycin, and Dexamethasone (VAD) in Myeloma [DOI]
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- 8 Cholesterol requirement of P3-X63-Ag8 and X63-Ag8.653 mouse myeloma cells for growth in vitro. [DOI]
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