Intra Nasal Delivery of Naringenin Loaded Cubosomal in Situ Gel: Formulation and In vitro/ In vivo Evaluation
Y.Indira Muzib, D R Aruna Kumari, Y.R. Ambedkar
Journal of Pharmaceutical Research International · pp. 94–112 · Published 9 Jun 2025
10.9734/jpri/2025/v37i67706Abstract
The main aim of this study was to develop naringenin-loaded cubosomes for intranasal administration, with a focus on assessing pharmacodynamic studies in animal models. The cubosomal system, composed of oleic acid, glycerol and poloxamer 407 was developed using top-down method. The physicochemical analysis of the naringenin-loaded cubosomes, including analysis of particle size, entrapment efficiency and t50%values of 199.01 ± 2.31 nm, 92.36 ± 2.91%, and 5.94 h respectively. From the in- vitro release, Ex-vivo studies cubosomal in-situ gel formulation (Gellan gum 0.45% w/v, Locust bean gum 1.58% and 3.0% w/v, PEG6000 2% w/v) showed significantly higher release compared to free naringenin. Pharmacodynamic studies confirms that the nasal administration group showed a delayed onset of action when compared to the oral administration group, suggesting a targeted effect.
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