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Research Article Open access CC BY 4.0

Investigating Boswellia serrata and Boswellic Acid for Huntington's Disease: Therapeutic Prospects

Pallavi V. Bhosle, Shailesh J. Wadher

International Neuropsychiatric Disease Journal · pp. 55–63 · Published 20 Aug 2024

10.9734/indj/2024/v21i5449

Abstract

Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), pose significant challenges to global healthcare systems due to their progressive nature and limited therapeutic options. In recent years, natural compounds have garnered attention for their potential neuroprotective effects. Boswellic acid, derived from the resin of Boswellia serrata, has emerged as a promising candidate for the treatment of neurodegenerative diseases. This comprehensive review explores the therapeutic potential of boswellic acid in AD, PD, and HD. The review begins by elucidating the neuroprotective mechanisms of boswellic acid, including its anti-inflammatory, antioxidant, and neurotrophic properties. Preclinical studies demonstrating the efficacy of boswellic acid in mitigating neurodegenerative processes are summarized, highlighting its ability to modulate key signaling pathways involved in neuronal survival and apoptosis. Furthermore, the review discusses the therapeutic implications and future perspectives of boswellic acid in neurodegenerative disorders, emphasizing the need for further research to validate its clinical efficacy. Overall, this review provides valuable insights into the neuroprotective effects of boswellic acid and its potential as a therapeutic agent for neurodegenerative diseases. Understanding the mechanisms underlying its beneficial effects may pave the way for the development of novel treatment strategies targeting these devastating conditions.

Alzheimer's disease boswellic acid Huntington's disease Parkinson's disease

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