Lead Anticancer Agents of Crinine Alkaloids: Cytotoxic, Caspase-3, and Anti-angiogenic Exploration
Asian Journal of Chemical Sciences · pp. 86–95 · Published 18 Sep 2023
10.9734/ajocs/2023/v13i5256Abstract
Several alkaloids with anticancer activities have been reported among the Crinum species. In this study, an in silico screening of crinine alkaloids was carried out to identify potential Caspase-3 activators and anti-angiogenic compounds. Thirty-one (31) crinine alkaloids were assessed for drug-likeness using the SwissADME online Web server. Nine (9) alkaloids, satisfying Lipinski’s rules for drug-likeness were selected and screened in silico for cytotoxic properties against cancer and normal cell lines using the Cell Line Cytotoxity Predictor (CLC-Pred). The alkaloids possessing drug-like properties and showing good selectivity towards cancer cell lines were evaluated for Caspase-3 activating and anti-angiogenic activities by docking with the Caspase-3 and VEGFR2 proteins, respectively. The binding energy of the compounds was compared with those of the standard drugs. Powelline, augustine, and undulatine possess drug-like properties and demonstrated good selectivity against lung cancer (A549) and oligodendroglioma (Hs683) cell lines. Among these three compounds, powelline had the best potential as a Caspase-3 stimulant and anti-angiogenic agent. Powelline, augustine, and undulatine are potential lead anticancer agents against human lung cancer and oligodendroglioma.
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