Lipid Profile, Haemoglobin Level and Antioxidant Effect of Pre-treatment with Methanolic Extract of Byrsocarpus coccineus Schum. & Thonn. Leaf against Carbon Tetrachloride-Induced Injuries to Liver, Kidney and Heart of Rats
Sunday Ene-Ojo Atawodi, Nuratu Abdullahi, Bature Edwin Igede, Isah Muktar Abu
Biotechnology Journal International · pp. 1291–1304 · Published 30 Oct 2014
10.9734/BBJ/2014/12719Abstract
Lipid Profile, Haemoglobin Level and Antioxidant Effect of Pre-treatment with Methanolic Extract of Byrsocarpus coccineus Schum. & Thonn. Leaf against Carbon Tetrachloride-Induced Injuries to Liver, Kidney and Heart of Rats Aim: To evaluate the protective and ameliorative roles of methanolic extract of Byrsocarpus coccineus, Schum. & Thonn. leaf against acute and chronic carbon tetrachloride (CCl4)-induced oxidative stress and Injuries to Liver, Kidney and Heart in Rats. Methods: To study the protective effects of the extract against oxidative stress, the rats were pre-treated with the extract (5mg/kg) for three days before intoxication with carbon tetrachloride (CCl4) at 0.6ml/kg as a 33% solution in corn oil, with Vitamin E (50mg/kg) as an antioxidant control. Results: Administration of the extract significantly (P=.05) prevented or reversed the CCl4 -induced elevation in the levels of aspartate aminotransaminase (AST), alanine amino transaminase (ALT), bilirubin, malondialdehyde, urea, creatinine, total cholesterol with boosting of the levels of superoxide dismutase (SOD), catalase, HDL-cholesterol, packed cell volume (PCV) and hemoglobin concentration. Conclusion: These results suggest that in addition to its hypolipidemic effect, methanolic extract of B. coccineus leaf can be used to protect and manage the liver and kidney against oxidative stress related injuries.
References (29)
- 1 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases [DOI]
- 2 Mechanisms of Hepatotoxicity [DOI]
- 3 Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action [DOI]
- 4 Enzymatic Determination of Total Cholesterol in Serum [DOI]
- 5 Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology [DOI]
- 6 Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death [DOI]
- 7 Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation [DOI]
- 8 Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes [DOI]
- 9 Evaluation of the Polyphenol Content and Antioxidant Properties of Methanol Extracts of the Leaves, Stem, and Root Barks of Moringa oleifera Lam. [DOI]
- 10 Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients [DOI]
- 11 Antiinflammatory activity of the aqueous leaf extract of Byrsocarpus coccineus [DOI]
- 12 Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model” [DOI]
- 13 Evaluation of the antimicrobial potential of medicinal plants from the Ivory Coast [DOI]
- 14 Screening of some Nigerian medicinal plants for antioxidant activity using 2,2, diphenyl-picryl-hydrazyl radical [DOI]
- 15 Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency [DOI]
- 16 Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency [DOI]
- 17 Drinking of Salvia officinalis tea increases CCl4-induced hepatotoxicity in mice [DOI]
- 18 Antioxidant, Hepatoprotective, and Ameliorative Effects of Methanolic Extract of Leaves of Grewia mollis Juss. on Carbon Tetrachloride–Treated Albino Rats [DOI]
- 19 Evaluation of the antidiarrhoeal activity of Byrsocarpus coccineus [DOI]
- 20 Quality evaluation of four hemoglobin screening methods in a blood donor setting along with their comparative cost analysis in an Indian scenario [DOI]
- 21 Antioxidant, hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication [DOI]
- 22 Anxiolytic and sedative effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) extract
- 23 Preliminary phytochemical and antimicrobial screening of the leaves of Byrsocarpus coccineus Schum & Thonn (Connaraceae) [DOI]
- 24 Analgesic activity of the aqueous leaf extract of Byrsocarpus coccineus [DOI]
- 25 In vivo antiplasmodial activity of byrsocarpus coccineus leaf extract in mice infected with plasmodium berghei [DOI]
- 26 Ethnomedicine Against Jaundice Used by Gond Tribes of Adilabad District, Andhra Pradesh, India
- 27 Uterotonic Properties of the Ethanol Extract of Brysocarpus coccineus [DOI]
- 28 Antipyretic Activity of Byrsocarpus coccineus Schum and Thonn. (Connaraceae) [DOI]
- 29 FORUM Mechanisms of Hepatotoxicity
Cited by 2
D. Ebenezer, Oladipo Faith Temiloluwa · International Journal of Pathogen Research · 2021
Related research
- The Prevalence of Prediabetes and Its Association with Metabolic Syndrome and Insulin Resistance in the Central Indian Population — shares topic coverage
- Cholesterol and Fatty Acid Profiles of Some Bird Egg Varieties: Possible Health Implications — shares topic coverage
- Effect of Estradiol Valerate on Serum Biochemical Profiles in Aged Female Albino Rats — shares topic coverage
- The Effect of Pleurotus tuberregium (An Oyster Mushroom) Sclerotia on the Weight, Protein Content and Lipid Profile of Broiler Chickens — shares topic coverage
- Total Cholesterol and Triglycerides in Unmarried Males and Females of Azad Jammu and Kashmir, Pakistan — shares topic coverage
Article metrics
Real usage data collected on this platform.
44
Page views
0
PDF downloads
8
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.