Metabolic and Hormonal Changes in Obese Subjects with and Without Diabetic Mellitus
Sherifa A. Hamed, Refaat F. Abd Elaal, Tahra K. Sherif
Journal of Advances in Medicine and Medical Research · pp. 1–12 · Published 30 Oct 2015
10.9734/BJMMR/2016/21457Abstract
Background: Increasing body weight is a risk factor for development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Aim: We aimed to determine the relationship between insulin, C-peptide, leptin, cortisol, growth hormone (GH) and adiposity in obese and subjects with T2DM as data regarding this issue are still controversial. Study Design: Cross sectional study. Methodology: this study included 60 patients with T2DM, 60 obese non-diabetics and 30 healthy controls. Anthropometric parameters, glycemic and lipid profiles, insulin, C-peptide, leptin, cortisol and GH were measured. Results: Serum C-peptide (P=0.025, P=0.030, P=0.021), insulin (P=0.0001 for all) and leptin (P=0.001, P=0.02, P=0.0001) were higher in obese (n=22) and non-obese diabetics (n=38) and obese non-diabetics versus controls. Cortisol was higher in obese non-diabetics versus obese (P=0.017) and non-obese (P=0.007) diabetics and controls (P=0.0001). GH was higher in obese non-diabetics versus obese diabetics (P=0.031). IR was reported in obese (72.70%) and non-obese (71.00%) diabetics and obese non-diabetics (38.30%). Central obesity was reported in obese (59.10%) and non-obese (34.20%) diabetics and obese non-diabetics (45.00%). In obese diabetics, a positive correlation was reported between leptin with C-peptide (P=0.001). In non-obese diabetics, positive correlations were reported between IR and cortisol (P=0.025) and waist/hip ratio (WHR) with insulin (P=0.029) but a negative correlation was reported between glycosylated hemoglobin (HBAIc) and leptin (P=0.047). In obese non-diabetics, positive correlations were reported between leptin with HbA1c (P=0.01) and cortisol (P=0.003), WHR with insulin (P=0.0001) and cortisol with leptin (P=0.003). Conclusion: The association of insulin and leptin resistances and hypercortisolemia with obesity supports the notion that the regulatory defects of blood glucose and obesity are associated with long-term metabolic complications.
Cited by 0
No indexed citations yet.
Related research
- Metabolic Syndrome among Healthcare Workers in a Tertiary Hospital in South-South, Nigeria — shares topic coverage
- Dietary Pattern and Prevalence of High Blood Pressure among Adult Traders in Port Harcourt, Nigeria — shares topic coverage
- Impact of the Diet Profile and Alcohol Consumption on Cardiometabolic Risks in Dschang Health District-Cameroon — shares topic coverage
- Gender Specific Predictive Performance and Optimal Threshold of Anthropometric Indices for the Prediction of Hypertension among a Ghanaian Population in Kumasi — shares topic coverage
- Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
30
Page views
0
PDF downloads
4
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.