Skip to content
Research Article Open access CC BY 4.0

Methanol Extract of Dryopteris dilatata Alleviates streptozotocin-induced Hyperglycaemia and Liver Injury in Male Wistar Rats in Type 2 Diabetes Mellitus

Ajirioghene E. Akpotu, Gospel Nwikue, A. I. L. Bassey, Silver D. Isosiya, Ajibo Doris, Ckikere A. Anusiem

Journal of Complementary and Alternative Medical Research · pp. 1–15 · Published 11 Nov 2022

10.9734/jocamr/2022/v19i3391

Abstract

Dysfunctional pancreatic beta cell and impaired glucose metabolism in the liver has been implicated in streptozotocin (STZ)-type 2 diabetes mellitus and this has been linked with increased oxidative stress. Whether methanol extract of Dryopteris dilatata (MEDd), a flavonoid-rich plant can ameliorate STZ- type 2 diabetes liver damage remains an issue. Hence, this study investigated the effect of methanol extract of Dryopteris dilatata on STZ- type 2 diabetes mellitus in male Wistar rat. Animals were randomly selected into five groups (n=5) and were treated as follows; group 1 received distilled water (10ml/kg), Group 2 received only STZ (60mg/kg), Group 3 and 4 received STZ then 400 and 800mg/kg of MEDd respectively while Group 5 received STZ then pioglitazone (10mg/kg). Following 14 days of treatment, animals were euthanized and blood as well as spleen, liver, pancreas and kidney tissues were collected for further studies. Our results revealed that MEDd significantly reduced STZ-induced hyperglycaemia in Diabetic rats. Markers of oxidative injury (MDA, NO and GSH) were also significantly ameliorated in the pancreas and liver of the diabetic rats following treatment with MEDd. However, liver injury markers (ALT, AST and ALP) were significantly attenuated with marked decreased in organ weight in the diabetic rats after treatment with MEDd. We found that methanol extract of Dryopteris dilatata demonstrated anti-diabetogenic and hepato-protective potential by enhancing in vivo hepato-pancreatic antioxidant defence system.

Dryopteris dilatata streptozotocin diabetes mellitus antioxidants liver injury

References (22)

  1. 1 The Proceedings of the National Academy of Sciences [DOI]
  2. 2 Mechanism linking diabetes mellitus and obesity [DOI]
  3. 3 Classification, Pathophysiology, Diagnosis and Management of Diabetes Mellitus [DOI]
  4. 4 Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction [DOI]
  5. 5 Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review [DOI]
  6. 6 Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB [DOI]
  7. 7 Role of Caveolin-1 in Diabetes and Its Complications [DOI]
  8. 8 Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures [DOI]
  9. 9 Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan [DOI]
  10. 10 Selective uptake of alloxan by pancreatic B-cells [DOI]
  11. 11 Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study [DOI]
  12. 12 Antidiabetic and antioxidant potentials of Vitellaria paradoxa barks in alloxan-induced diabetic rats [DOI]
  13. 13 High dietary salt intake alleviates fasting blood glucose in streptozotocin-induced diabetic male Wistar rats [DOI]
  14. 14 Chrysophyllum albidum fruit ethanol extract ameliorates hyperglycaemia and elevated blood pressure in streptozotocin-induced diabetic rats through modulation of oxidative stress, NF-κB and PPAR-γ [DOI]
  15. 15 Tithonia diversifolia aqueous fraction plays a protective role against alloxan-induced diabetic mice via modulating GLUT2 expression [DOI]
  16. 16 The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats [DOI]
  17. 17 Antidiabetic and anti- hyperlipidemic effects of ethanolic extract of Dryopteris dilatata leaves [DOI]
  18. 18 Effect of Diabetes Mellitus and Hypertension on Osmotic Fragility and Hemorheological Factors in Male Wistar Rats [DOI]
  19. 19 The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats [DOI]
  20. 20 BEHAVIORAL AND BIOCHEMICAL EVIDENCES FOR ANTIDEPRESSANT ACTIVITY OF ETHANOL EXTRACT OF Jatropha curcas IN MICE SUBJECTED TO CHRONIC UNPREDICTABLE MILD STRESS
  21. 21 Oxidative Medicine and Cellular Longevity [DOI]
  22. 22 Journal of Physiology and Biochemistry [DOI]

Cited by 1

Attenuating Effect of Fraction of Dryopteris dilatata on Alloxan-induced Oxidative Stress and Hepato-nephro Injury in Wistar Rat Models

Ajirioghene E. Akpotu, Samuel I. Ghasi, Ehoro O. Odu · European Journal of Medicinal Plants · 2025

Article metrics

Real usage data collected on this platform.

39

Page views

0

PDF downloads

5

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.