Skip to content
Research Article Open access CC BY 4.0

Microwave Supported Solvent Free Reaction of EMME in the Synthesis of Pyrazolopyrimidopyrimidines

D. Shah Rina, M. Shah Nirmal, C. Ramani Vivek

Asian Journal of Applied Chemistry Research · pp. 1–9 · Published 24 Apr 2018

10.9734/ajacr/2018/v1i19602

Abstract

Diethyl ethoxy-methylenemalonate the versatile reagent used to synthesize pyrazolopyrimidopyrimidines (3) as antimicrobial agents from the reaction between EMME and 1-substituted 3-(methylthio) 3H-pyrazolo [3,4-d]pyrimidine-4-amines (1) using Gould Jacob reaction. A comparison of conventional and microwave supported solvent-free reaction has been studied.

EMME pyrazolopyrimidopyrimidines Gould-Jacob reaction microwave heating

References (14)

  1. 1 Controlled Microwave Heating in Modern Organic Synthesis [DOI]
  2. 2 Microwave assisted organic synthesis—a review [DOI]
  3. 3 Microwave assisted organic reactions [DOI]
  4. 4 New Solvent-Free Organic Synthesis Using Focused Microwaves [DOI]
  5. 5 Solvent-free accelerated organic syntheses using microwaves [DOI]
  6. 6 The Synthesis of Certain Substituted Quinolines and 5,6-Benzoquinolines [DOI]
  7. 7 Thermal reactions of cyclopropenone ketals. Key mechanistic features and scope of the cycloaddition reactions of delocalized singlet vinylcarbenes: three-carbon 1,1-/1,3-dipoles [DOI]
  8. 8 Highly stereoselective total synthesis of .beta.-ribofuranosylmalonate [DOI]
  9. 9 Synthesis and Biological Evaluation of Some Novel Fused Pyrazolopyrimidines as Potential Anticancer and Antimicrobial Agents [DOI]
  10. 10 Selective Dealkylations of Alkyl Aryl Ethers in Heterogeneous Basic Media under Microwave Irradiation. [DOI]
  11. 11 Studies on the syntheses of heterocyclic compounds and natural products. 999. Double enamine annelation of 3,4-dihydro-1-methyl-.beta.-carboline and isoquinoline derivatives with 6-methyl-2-pyrone-3,5-dicarboxylates and its application for the synthesis of (.+-.)-camptothecin [DOI]
  12. 12 Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats [DOI]
  13. 13 ChemInform Abstract: The Chemistry of Pyrazolopyrimidines and Their Applications [DOI]
  14. 14 The gould-jacob type of reaction for the synthesis of novel pyrimidopyrrolopyrimidines: A comparison of classical heatingvssolvent free microwave irradiation [DOI]

Cited by 2

Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6- a ]pyrimidine and pyrimido[1,6- c ]pyrimidine scaffolds

Khaled M. Elattar, Başak Doğru Mert, M. Monier · RSC Advances · 2020

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

17

Page views

0

PDF downloads

3

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.