Skip to content
Research Article Open access CC BY 4.0

Natural Bioactive Compounds against Schistosoma haematobium and Schistosoma mansoni

Aristide Ouattara, Harouna SORE, Adama Zida

International Journal of TROPICAL DISEASE & Health · pp. 41–56 · Published 4 Mar 2024

10.9734/ijtdh/2024/v45i31523

Abstract

Aim: This documentary review aimed to make a synthesis of bioactive plants or natural compounds on schistosomes. We carried out a review from 2000 to 2022, oriented towards the plants in order to search natural compounds bioactive on schistosomes which can be a great contribution for new drugs discovering. Terms such as “schistosomiasis and medicinal plants”, “natural anti-schistosome compounds”, “phytochemical screening”, “bioactive compounds on schistosomes” were used for the online literature search through the following sites: PubMed; Google Scholar; ScienceDirect and Hinari. Results: There are many plants already used for the traditional treatment of schistosomiasis. This review found nearly 72 families of plants belonging to 228 botanical species have been listed. Some of these have been studied in vitro / in vivo and preliminary results have shown their schistosomicidal properties. Moreover, the results of qualitative phytochemical screening and toxicity testing of these natural compounds provide hope for new drug discoveries. Conclusion: Even if plants efficacy is proven, we need more in-depth investigations to determine their chemical components in order to minimize the undesirable effects and to guarantee their safety by assessing their toxicity.

Schistosomiasis schistosoma praziquantel natural compounds bioactive

References (15)

  1. 1 In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization [DOI]
  2. 2 A safe, effective, herbal antischistosomal therapy derived from myrrh. [DOI]
  3. 3 Sativa seeds against Schistosoma mansoni different stages [DOI]
  4. 4 Anthelmintic activity in vitro and in vivo of Baccharis trimera (Less) DC against immature and adult worms of Schistosoma mansoni [DOI]
  5. 5 RETRACTED: Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial [DOI]
  6. 6 Abrus Precatorius (L.): An Evaluation of Traditional Herb
  7. 7 In vitro effect of curcumin on Schistosoma species viability, tegument ultrastructure and egg hatchability [DOI]
  8. 8 Potent Schistosomicidal Constituents from Garcinia brasiliensis [DOI]
  9. 9 In Vitro Antischistosomal Activity of the Argemone mexicana Methanolic Extract and Its Main Component Berberine [DOI]
  10. 10 Plant extracts and compounds for combating schistosomiasis [DOI]
  11. 11 Parasitological and Biochemical Efficacy of the Active Ingredients of Allium sativum and Curcuma longa in Schistosoma mansoni Infected Mice [DOI]
  12. 12 Antischistosomal Effects of Selected Methanolic Plant Extracts in Swiss Albino Mice Infected with Schistosoma mansoni [DOI]
  13. 13 In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR [DOI]
  14. 14 In Vitro and in Vivo Activity of Allicin against Schistosoma Mansoni [DOI]
  15. 15 Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation [DOI]

Cited by 2

Effectiveness of Chromolaena odorata Extracts Against Cercariae From Schistosoma mansoni : Pharmacological Related Properties and Phytochemical Profile

Dongmo Nguepi Mireille Sylviane, Itoe Ubre Sicca, Sofeu Feugaing David Denis · Biomedical Chromatography · 2026

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

13

Page views

0

PDF downloads

1

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.