Neuroprotective Effect of Ethanol Extract of Moringa oleifera Leaf on the Neurofibres of Cerebellum of Quinine-treated Adult Wistar Rats
I. U. Umoh, I. A. Edagha, A. N. Aquaisua
Asian Journal of Research in Medical and Pharmaceutical Sciences · pp. 1–10 · Published 14 Aug 2018
10.9734/AJRIMPS/2018/42865Abstract
Aim: The neuroprotective effect of ethanol extract of Moringa oleifera leaf on the myelin and neurofibres of cerebellum in quinine treated adult Wistar rats was studied. Place of Study: Department of Anatomy, University of Uyo, Uyo, Akwa Ibom State, Nigeria. Study Design: Thirty-five (35) rats weighing between 180 – 200 g were randomly assigned into seven groups of 5 rats each. Group 1 served as the control while Groups 2 - 7 were the experimental groups. Groups 2 - 4 received 10 mg/kg, 20 mg/kg and 30 mg/kg body weight of quinine hypochloride injection intramuscularly eight hourly for seven days, respectively. Animals in Group 5 were administered 250 mg/kg of Moringa oleifera leaf extracts and 10 mg/kg body weight of quinine; Group 6, 500 mg/kg of the extracts and 20 mg/kg of quinine while Group 7 received 750 mg/kg of extracts and 30 mg/kg quinine, all for 7 days. Methodology: Twenty-four hours after final administration, the animals were sacrificed under chloroform inhalational anesthesia. Brain tissues were perfused with phosphate buffered solution, harvested and processed for histomorphological observations of the myelin and neurofibres of the cerebellum using Belcshowsky and Marchi’s staining techniques. Results: Results revealed that quinine caused neuronal distortions, nuclear degenerations, thickened neurofibres, vascular congestions, degenerative changes on myelin with vacuolations in the cerebellum. Incorporation of the Moringa oleifera extract to the quinine treated groups revealed neuronal regenerations and restoration of normal cerebellar cyto-architecture. Conclusion: The results revealed that Moringa oleifera leaf extract has neuroprotective effects on the myelin and neurofibres when exposed to quinine neurotoxicity.
References (15)
- 1 The biochemistry and medical significance of the flavonoids [DOI]
- 2 Antioxidant Properties of Various Solvent Extracts of Total Phenolic Constituents from Three Different Agroclimatic Origins of Drumstick Tree ( Moringa oleifera Lam.) Leaves [DOI]
- 3 Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats [DOI]
- 4 Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera [DOI]
- 5 Lipidosis induced by amphiphilic cationic drugs [DOI]
- 6 Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: Evaluation using adult mice treated with trimethyltin chloride as a model [DOI]
- 7 Case Management of Severe Malaria - A Forgotten Practice: Experiences from Health Facilities in Uganda [DOI]
- 8 Audiometry as a possible indicator of quinine plasma concentration during treatment of malaria [DOI]
- 9 Moringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral Ischemia [DOI]
- 10 Quinine Loading Dose in Cerebral Malaria [DOI]
- 11 Quinine overdose: Review of toxicity and treatment [DOI]
- 12 Pharmacokinetics of quinine and 3-hydroxyquinine in severe falciparum malaria with acute renal failure [DOI]
- 13 Toxicity of commonly-used antimalarial drugs [DOI]
- 14 Discharge patterns of Purkinje cells in cats anaesthetized with alpha‐chloralose. [DOI]
- 15 Toxicological Evaluation of Some Artemisinin Combination Therapies (ACTs) on the Kidney and Liver of Albino Wistar Rats [DOI]
Cited by 7
Priya Kumari, S. Ramesh Kumar · Journal of Agriculture and Food Research · 2025
Piyush Kashyap, Shiv Kumar, Charanjit Singh Riar · Antioxidants · 2022
Zarina, Ab Waheed Wani, Monisha Rawat · Food Science & Nutrition · 2024
Showing 3 of 7 known citations — external sources report more than can currently be individually listed.
Related research
- Ameliorative Potentials of Yoyo Bitters and Aqueous Leaf Extract of Moringa oleifera in Arsenite Induced Inflammatory Dysfunctions in Male Wistar Rats — shares topic coverage
- Morphological and Biochemical Effects of Aqueous Extract of Moringa oleifera Leaf on Cobalt Chloride-Induced Cerebral Damage in Adult Wistar Rats — shares topic coverage
- Antimicrobial Activity of Moringa oleifera Leaf against Isolates of Beef Offal — shares topic coverage
- Phytochemical Profiling and Anti-MRSA Activity of Extracts from Moringa oleifera Lam. and Senna occidentalis (L.) Link Cultivated under Organic Conditions — shares topic coverage
- Influence of Moringa oleiferea Seed Meal and Yam Blend in Body Weight and Glucose Level of Alloxan Induced Diabetes Mellitus Male Albino Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
53
Page views
0
PDF downloads
4
Outbound clicks
7
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.