Skip to content
Research Article Open access CC BY 4.0

Opioid System (β-endorphin) and Stress Hormones Profiling in Women with Polycystic Ovary Syndrome

F. Z. Zangeneh, M. M. Naghizadeh, A. Abdollahi, N. Abedinia

Annual Research & Review in Biology · pp. 409–418 · Published 5 Nov 2014

10.9734/ARRB/2015/12932

Abstract

Aims: In this study, we investigated serumβ-endorphin and its feedback system in women with polycystic ovary syndrome (PCO). Experimental and clinical studies show that there is an over activity of sympathetic nervous system in PCOS. It affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Study Area and Duration of Study: This study was carried out at Vali-e-Asr Clinic, a Reproductive Health Research Center, affiliated to Tehran University of Medical Sciences between February 2012 and April 2013. Methodology: 77 women with PCO were studied with diagnose criteria and within the age range of 20-40 years without special disease. Stress neurohormones, beta-endorphine and melatonin serum levels were measured in study group and were compared with healthy women as control group. A questionnaire with items related to pieces of information about stress was used for data collection. Stress symptoms were assessed using the Understanding Yourself questionnaire. Statistical analyses were performed using SPSS Ver. 13.0 (SPSS Inc., Chicago, ILL, USA). The data are presented as mean ± SD or as frequency with percentages. A p-value less than 0.05 were considered as statistically significant. Results: Data of serum levels of neurohormones showed, beta endorphin decreased (P<0.001) and adrenaline increased (P<0.001) in women with PCO. Significantly inhibited the opioid system may be one of the main reasons of the hyperactivity in two super systems: HPA and sympathetic nervous system. Conclusion: Earlier reports stated that opioid system decreases sympathetic tone in the brain in normal condition, our results in this study confirm the over activity of sympathetic nervous system which was due to decreasing opioid system activity in women with polycystic ovary syndrom (PCO).

Polycystic ovary syndrome (PCOS) stress opioid system β-endorphin adrenaline cortisol.

References (28)

  1. 1 A Syndrome produced by Diverse Nocuous Agents [DOI]
  2. 2 Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan [DOI]
  3. 3 Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications [DOI]
  4. 4 Treatment options for polycystic ovary syndrome [DOI]
  5. 5 Circadian rhythms, sleep, and the menstrual cycle [DOI]
  6. 6 Neuroendocrine aspects of the response to stress [DOI]
  7. 7 Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society [DOI]
  8. 8 Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management. [DOI]
  9. 9 Regulation of Human Affective Responses by Anterior Cingulate and Limbic µ-Opioid Neurotransmission [DOI]
  10. 10 Polycystic Ovary Syndrome [DOI]
  11. 11 Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial [DOI]
  12. 12 Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome [DOI]
  13. 13 The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target? [DOI]
  14. 14 Physiology of the Hypothalamic-Pituitary-Adrenal Axis in Health and Dysregulation in Psychiatric and Autoimmune Disorders [DOI]
  15. 15 Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain [DOI]
  16. 16 The effect of polycystic ovary syndrome on health-related quality of life [DOI]
  17. 17 The Relationship between Clinico-Biochemical Characteristics and Psychiatric Distress in Young Women with Polycystic Ovary Syndrome [DOI]
  18. 18 Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome [DOI]
  19. 19 Opioid-Adrenergic-Steroid Connection in Regulation of Luteinizing Hormone Secretion in the Rat [DOI]
  20. 20 Opposing regulation of the locus coeruleus by corticotropin-releasing factor and opioids [DOI]
  21. 21 Robust enkephalin innervation of the locus coeruleus from the rostral medulla [DOI]
  22. 22 The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat [DOI]
  23. 23 Cortisol and the polycystic ovary syndrome [DOI]
  24. 24 Psychological distress in women with polycystic ovary syndrome from imam khomeini hospital, tehran.
  25. 25 Endogenous opioid peptides and hypothalamic neuroendocrine neurones [DOI]
  26. 26 α2-Adrenoreceptor subtypes regulate ACTH and β-endorphin secretions during stress in the rat [DOI]
  27. 27 Neonatal testosterone modifies LH secretion in the adult female rat by altering the opioid-noradrenergic interaction in the medial preoptic area [DOI]
  28. 28 Allostasis and Allostatic Load [DOI]

Cited by 8

Neuropeptide Network of Polycystic Ovary Syndrome – A Review

Dheepthi Jayamurali, Nivetha Ravishankar, Nivedita Manoharan · Protein & Peptide Letters · 2024

Opioid peptides: physiological role, molecular mechanisms and pharmacological activity

M.U. Sergalieva, A.A. Tsibizova, T.A. Krintsova · Russian Journal of Pain · 2023

Showing 5 of 8 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

29

Page views

0

PDF downloads

3

Outbound clicks

8

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.