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Research Article Open access CC BY 3.0

Optimized Artemether-loaded Anhydrous Emulsion

N. C. Obitte, L. C. Rohan, C. M. Adeyeye, C. O. Esimone

Journal of Pharmaceutical Research International · pp. 37–59 · Published 5 Oct 2013

10.9734/BJPR/2014/5279

Abstract

Objective: The objectives of this study were to identify stable anhydrous emulsions via pseudo ternary phase diagram, optimize artemether-loaded batches using factorial design and subsequently evaluate the antimalarial activity. Methodology: Using labrasol®, triacetin® and lauroglycol 90® as the surfactant, oil and co-surfactant respectively, pseudo ternary phase diagram was generated from the quantitative titration of water with the anhydrous emulsion. Stable combinations from the phase diagram were subjected to a 23 full factorial experimental design. The 22 software-generated formulations were experimentally formulated and characterized for droplet size, polydispersity index, viscosity and thermodynamic stability. Droplet size was chosen and subsequently fitted into the Response column of the software, thus prompting the generation of graphs and Desirability table of 125 predicted formulations. Out of the 125 predictions, three with the least droplet sizes (less than 100 nm) were adjudged as optimized batches. Subsequently, they were formulated, converted to powder by adsorption on magnesium aluminum metasilicate and evaluated. Antimalarial effectiveness of the drug-loaded formulation was also investigated. Results: Triacetin® most significantly (P<0.05) contributed to droplet size variation. The droplet size of the experimental formulations approximated that of the statistical predictions. The anhydrous emulsions (AEs) were powderable and the granulations rated fair and passable according to Carr’s scale. Artemether-loaded anhydrous emulsion (AE) demonstrated highest antimalarial activity. Conclusion: We therefore conclude that optimization proved a useful tool for the identification of excipient proportions with optimal effects.

Anhydrous emulsion optimized pseudoternary phase diagram droplet size Flow properties antimalarial activity.

References (35)

  1. 1 The Theory and Practice of Industrial Pharmacy
  2. 2 Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies [DOI]
  3. 3 Transparent Water-in-Oil Dispersions: the Oleopathic Hydro-Micelle [DOI]
  4. 4 Antimalarial drug discovery: efficacy models for compound screening [DOI]
  5. 5 Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs [DOI]
  6. 6 Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update [DOI]
  7. 7 Formulation development and optimization using nanoemulsion technique: A technical note [DOI]
  8. 8 Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib [DOI]
  9. 9 Phospholipids and Lipid-Based Formulations in Oral Drug Delivery [DOI]
  10. 10 Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system [DOI]
  11. 11 Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate [DOI]
  12. 12 Entropy-induced dispersion of bulk liquids [DOI]
  13. 13 CLASSIFYING FLOW PROPERTIES OF SOLIDS
  14. 14 Improved Drug Delivery Using Microemulsions: Rationale, Recent Progress, and New Horizons [DOI]
  15. 15 Self-Emulsifying Drug Delivery Systems: Strategy for Improving Oral Delivery of Poorly Soluble Drugs [DOI]
  16. 16 Preparation and Bioavailability Assessment of SMEDDS Containing Valsartan [DOI]
  17. 17 Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation [DOI]
  18. 18 Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen [DOI]
  19. 19 X-ray investigation of the structure of transparent oil-water disperse systems. I [DOI]
  20. 20 Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters [DOI]
  21. 21 Transport of lipophilic molecules by the intestinal lymphatic system [DOI]
  22. 22 Clinical Pharmacokinetics of Artemether and Lumefantrine (Riamet??) [DOI]
  23. 23 A Novel Itraconazole Bioadhesive Film for Vaginal Delivery: Design, Optimization, and Physicodynamic Characterization [DOI]
  24. 24 Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria [DOI]
  25. 25 Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS) [DOI]
  26. 26 Optimization of Sustained-Release Propranolol Dosage form Using Factorial Design and Response Surface Methodology [DOI]
  27. 27 Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation [DOI]
  28. 28 Optimization of polylactic-co-glycolic acid nanoparticles containing itraconazole using 23 factorial design [DOI]
  29. 29 Evaluation of starch obtained from Ensete ventricosum as a binder and disintegrant for compressed tablets [DOI]
  30. 30 Water Solubilization in Mixed Nonionic Surfactants Microemulsions [DOI]
  31. 31 Novel Modified Nanosystem Based Lymphatic Targeting [DOI]
  32. 32 Buccal Bioadhesive Delivery System of 5-Fluorouracil: Optimization and Characterization [DOI]
  33. 33 OPTIMIZATION OF ASCORBIC ACID TABLET FORMULATIONS CONTAINING HYDROPHILIC POLYMERS
  34. 34 Response surface methodology for the optimization of celecoxib self-microemulsifying drug delivery system [DOI]
  35. 35 In vivo Evaluation and Application of Central Composite Design in the Optimization of Amisulpride Self-Emulsifying Drug Delivery System [DOI]

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