Skip to content
Research Article Open access CC BY 4.0

Oxidative Stress in Ghanaians Presenting with Prostate Cancer

C. K. Gyasi-Sarpong, Idriss Ali, W. K. B. A. Owiredu

Journal of Advances in Medicine and Medical Research · pp. 1–8 · Published 5 Apr 2016

10.9734/BJMMR/2016/25093

Abstract

Introduction: The latest estimates of global cancer incidence show that prostate cancer has become the second most common cancer among men in the world. A number of reports have linked oxidative stress to prostate cancer. Although oxidative stress has been found to be much prevalent among the Ghanaian population, no data exist on its prevalence among prostate cancer patients in Ghana. This study therefore sought to investigate oxidative stress in Ghanaians presenting with prostate cancer. Methods: This cross-sectional study was conducted at the out-patient department of the department of surgery, Komfo Anokye Teaching Hospital, Kumasi, between the period of November, 2010 and April, 2012. In all, one hundred and twenty four (124) adult males (87 case subjects and 37 control subjects) aged at least forty two years were enrolled. Results: Malondialdehyde, an oxidative stress marker, and uric acid were significantly raised whereas the measured antioxidant (vitamin C) was significantly reduced among the prostate cancer patients compared to the controls. The indication is that oxidative stress with reduced antioxidant levels is common in prostate cancer patients.   Conclusion: Oxidative stress may have a significant role in prostate cancer. Based on the findings, it may seem reasonable to propose that therapeutic regimens aimed at beefing up the antioxidant defences could help offer some degree of protection for prostate cancer patients against oxidative stress.

Prostate cancer oxidative antioxidant malondialdehyde peroxidation polyunsaturated phospholipid

References (16)

  1. 1 Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [DOI]
  2. 2 Estimates of the cancer incidence and mortality in Europe in 2006 [DOI]
  3. 3 Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury [DOI]
  4. 4 Cancer burden in the year 2000. The global picture [DOI]
  5. 5 Oxidative Stress, Prooxidants, and Antioxidants: The Interplay [DOI]
  6. 6 Towards the physiological function of uric acid [DOI]
  7. 7 Oxy radicals, lipid peroxidation and DNA damage [DOI]
  8. 8 Cancer incidence and mortality in the European Union: Cancer registry data and estimates of national incidence for 1990 [DOI]
  9. 9 Molybdenum-containing hydroxylases [DOI]
  10. 10 A rapid and sensitive method for the determination of ascorbic acid using 4,7-diphenyl-1,10-phenanthroline. [DOI]
  11. 11 Uric Acid as a Prognostic Factor for Survival Time: A Prospective Cohort Study of Terminally Ill Cancer Patients [DOI]
  12. 12 Advanced but Not Localized Prostate Cancer is Associated With Increased Oxidative Stress [DOI]
  13. 13 Comparison of the concentration of trace metals (Ni, Zn, Co, Cu and Se), Fe, vitamins A, C and E, and lipid peroxidation in patients with prostate cancer [DOI]
  14. 14 A higher prediagnostic insulin level is a prospective risk factor for incident prostate cancer [DOI]
  15. 15 Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with pregnancy--induced hypertension.
  16. 16 Plasma anti‐oxidant status and lipid profile in non‐gravida women with a history of pre‐eclampsia [DOI]

Cited by 1

The Effect of Arbutin on The Expression of Tumor Suppressor P53, BAX/BCL-2 Ratio and Oxidative Stress Induced by Tert-Butyl Hydroperoxide in Fibroblast and LNcap Cell Lines

Shima Ebadollahi, M. Pouramir, E. Zabihi · Cell journal · 2020

Related research

Article metrics

Real usage data collected on this platform.

28

Page views

0

PDF downloads

4

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.